ACHB4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACHB4_HUMAN
• UniProt AC: P30926
• Protein Name: Neuronal acetylcholine receptor subunit beta-4
• Gene Name: CHRNB4
• Organism: Homo sapiens (Human).
• Sequence Length: 498
• Subcellular Localization: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
• Protein Description: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane..
• Protein Sequence: MRRAPSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAFPPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRFRQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLPPLFQTHAASEGPYAAQRD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	N-linked_Glycosylation	KLMDDLLNKTRYNNL HHHHHHHHHHCCCCC	51.45	UniProtKB CARBOHYD
76	Phosphorylation	NEREQIMTTNVWLKQ CHHHHHHEEEEEECC	19.49	26074081
77	Phosphorylation	EREQIMTTNVWLKQE HHHHHHEEEEEECCC	15.47	26074081
86	Phosphorylation	VWLKQEWTDYRLTWN EEECCCCCCCEEEEC	23.54	26074081
88	Phosphorylation	LKQEWTDYRLTWNSS ECCCCCCCEEEECCC	10.51	26074081
93	N-linked_Glycosylation	TDYRLTWNSSRYEGV CCCEEEECCCCCCCC	25.52	UniProtKB CARBOHYD
118 (in isoform 2)	Phosphorylation	-	8.76	22210691
138	N-linked_Glycosylation	TNLIVRSNGSVLWLP CEEEEECCCCEEECC	35.87	UniProtKB CARBOHYD
166	N-linked_Glycosylation	YFPFDQQNCTLKFRS ECCCCCCCCEEEEEE	18.33	UniProtKB CARBOHYD
211	Phosphorylation	VALPGRRTVNPQDPS EEECCCCCCCCCCCC	24.23	25072903
218	Phosphorylation	TVNPQDPSYVDVTYD CCCCCCCCCEEEEEE	46.18	25072903
219	Phosphorylation	VNPQDPSYVDVTYDF CCCCCCCCEEEEEEE	13.17	25072903
223	Phosphorylation	DPSYVDVTYDFIIKR CCCCEEEEEEEEECC	16.95	25072903
224	Phosphorylation	PSYVDVTYDFIIKRK CCCEEEEEEEEECCC	14.54	25072903
282	Phosphorylation	TFFLLLISKIVPPTS HHHHHHHHHHCCCCC	19.12	-
354	Phosphorylation	MKRPGPDSSPARAFP ECCCCCCCCCCCCCC	41.16	29449344
355	Phosphorylation	KRPGPDSSPARAFPP CCCCCCCCCCCCCCC	29.93	29449344
363	Phosphorylation	PARAFPPSKSCVTKP CCCCCCCCCCCCCCC	37.12	29449344

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACHB4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACHB4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACHB4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBQL1_MOUSE	Ubqln1	physical	16091357

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.