ACHA7_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACHA7_MOUSE
• UniProt AC: P49582
• Protein Name: Neuronal acetylcholine receptor subunit alpha-7
• Gene Name: Chrna7
• Organism: Mus musculus (Mouse).
• Sequence Length: 502
• Subcellular Localization: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
• Protein Description: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin..
• Protein Sequence: MCGRRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGTHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	N-linked_Glycosylation	PLERPVANDSQPLTV CCCCCCCCCCCCCEE	50.10	-
90	N-linked_Glycosylation	TDHYLQWNMSEYPGV CHHHHCCCCCCCCCC	15.90	-
133	N-linked_Glycosylation	FHTNVLVNASGHCQY EECCEEECCCCCCCC	24.99	-
217	Phosphorylation	YECCKEPYPDVTYTV HHHCCCCCCCCEEEE	17.10	-
221	Phosphorylation	KEPYPDVTYTVTMRR CCCCCCCEEEEEECC	22.36	-
365	Phosphorylation	QHKPRRCSLASVELS CCCCCCCEEEEEEEC	25.76	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
365	S	Phosphorylation	Kinase	PKACA	P05132	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACHA7_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACHA7_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.