| UniProt ID | ACHA7_HUMAN | |
|---|---|---|
| UniProt AC | P36544 | |
| Protein Name | Neuronal acetylcholine receptor subunit alpha-7 | |
| Gene Name | CHRNA7 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 502 | |
| Subcellular Localization |
Cell junction, synapse, postsynaptic cell membrane Multi-pass membrane protein. Cell membrane Multi-pass membrane protein. |
|
| Protein Description | After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.. | |
| Protein Sequence | MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 30 | Phosphorylation | GEFQRKLYKELVKNY HHHHHHHHHHHHHHC | 12.88 | 22964224 | |
| 46 | N-linked_Glycosylation | PLERPVANDSQPLTV CCCCCCCCCCCCCEE | 50.10 | UniProtKB CARBOHYD | |
| 83 | Phosphorylation | IWLQMSWTDHYLQWN EEEEEECCHHHHCCC | 12.94 | - | |
| 86 | Phosphorylation | QMSWTDHYLQWNVSE EEECCHHHHCCCHHH | 11.91 | - | |
| 90 | N-linked_Glycosylation | TDHYLQWNVSEYPGV CHHHHCCCHHHCCCC | 17.93 | UniProtKB CARBOHYD | |
| 133 | N-linked_Glycosylation | FHTNVLVNSSGHCQY EECCEEECCCCCCCC | 26.71 | UniProtKB CARBOHYD | |
| 217 | Phosphorylation | YECCKEPYPDVTFTV HHHHCCCCCCCEEEE | 17.10 | - | |
| 221 | Phosphorylation | KEPYPDVTFTVTMRR CCCCCCCEEEEEECC | 22.44 | - | |
| 225 | Phosphorylation | PDVTFTVTMRRRTLY CCCEEEEEECCCHHH | 11.25 | - | |
| 386 | Phosphorylation | ASNGNLLYIGFRGLD CCCCCEEEEEECCCC | 11.36 | 16251431 | |
| 442 | Phosphorylation | KILEEVRYIANRFRC HHHHHHHHHHHHHCC | 15.01 | 16251431 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 386 | Y | Phosphorylation | Kinase | SRC | P12931 | PSP |
| 386 | Y | Phosphorylation | Kinase | SRC64 | - | PhosphoELM |
| 442 | Y | Phosphorylation | Kinase | SRC | P12931 | PSP |
| 442 | Y | Phosphorylation | Kinase | SRC64 | - | PhosphoELM |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ACHA7_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ACHA7_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| D00611 | Mecamylamine hydrochloride (USP); Inversine (TN) | |||||
| D00999 | Acetylcholine chloride (JP16/USP/INN); Miochol (TN) | |||||
| D02202 | Lobeline hydrochloride (JAN) | |||||
| D02204 | Hexamethonium bromide (JAN/INN); Hexamethonium bromide (TN) | |||||
| D02364 | Lobeline (INN) | |||||
| D02839 | Altinicline maleate (USAN) | |||||
| D08138 | Lobeline sulfate; Smokeless (TN) | |||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
