dbPTM

ACER3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ACER3_HUMAN
UniProt AC	Q9NUN7
Protein Name	Alkaline ceramidase 3
Gene Name	ACER3
Organism	Homo sapiens (Human).
Sequence Length	267
Subcellular Localization	Endoplasmic reticulum membrane Multi-pass membrane protein. Golgi apparatus membrane Multi-pass membrane protein.
Protein Description	Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity..
Protein Sequence	MAPAADREGYWGPTTSTLDWCEENYSVTWYIAEFWNTVSNLIMIIPPMFGAVQSVRDGLEKRYIASYLALTVVGMGSWCFHMTLKYEMQLLDELPMIYSCCIFVYCMFECFKIKNSVNYHLLFTLVLFSLIVTTVYLKVKEPIFHQVMYGMLVFTLVLRSIYIVTWVYPWLRGLGYTSLGIFLLGFLFWNIDNIFCESLRNFRKKVPPIIGITTQFHAWWHILTGLGSYLHILFSLYTRTLYLRYRPKVKFLFGIWPVILFEPLRKH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	N-linked_Glycosylation	TLDWCEENYSVTWYI CCHHHHHHCCCHHHH	16.46	UniProtKB CARBOHYD
83	Phosphorylation	GSWCFHMTLKYEMQL CHHHHHHHHHHHHHH	16.13	68733349
99	Phosphorylation	DELPMIYSCCIFVYC HHHHHHHHHHHHHHH	7.50	113136059
105	Phosphorylation	YSCCIFVYCMFECFK HHHHHHHHHHHHHHH	2.77	113136065
124	Phosphorylation	VNYHLLFTLVLFSLI CCHHHHHHHHHHHHH	18.87	46157561
133	Phosphorylation	VLFSLIVTTVYLKVK HHHHHHHHHHHHHHC	11.98	46157567

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ACER3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ACER3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ACER3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ACER3_HUMAN !!

Drug and Disease Associations

Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ACER3_HUMAN

Related Literatures of Post-Translational Modification