dbPTM

ACC2_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ACC2_ARATH
UniProt AC	F4I1L3
Protein Name	Acetyl-CoA carboxylase 2
Gene Name	ACC2
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	2355
Subcellular Localization	Cytoplasm, cytosol .
Protein Description	Multifunctional enzyme that catalyzes the carboxylation of acetyl-CoA, forming malonyl-CoA, which is used in the plastid for fatty acid synthesis and in the cytosol in various biosynthetic pathways including fatty acid elongation..
Protein Sequence	MEMRALGSSCSTGNGGSAPITLTNISPWITTVFPSTVKLRSSLRTFKGVSSRVRTFKGVSSTRVLSRTKQQFPLFCFLNPDPISFLENDVSEAERTVVLPDGSVNGAGSVNGYHSDVVPGRNVAEVNEFCKALGGKRPIHSILVATNGMAAVKFIRSVRTWAYETFGSEKAVKLVAMATPEDMRINAEHIRIADQFVEVPGGTNNNNYANVQLIVEMAEVTRVDAVWPGWGHASENPELPDALKEKGIIFLGPPADSMIALGDKIGSSLIAQAADVPTLPWSGSHVKIPPGRSLVTVPEEIYKKACVYTTEEAIASCQVVGYPAMIKASWGGGGKGIRKVHNDDEVRALFKQVQGEVPGSPIFIMKVASQSRHLEAQLLCDQYGNVAALHSRDCSVQRRHQKIIEEGPITVAPQETIKKLEQAARRLAKSVNYVGAATVEYLYSMDTGEYYFLELNPRLQVEHPVTEWIAEVNLPAAQVAVGMGIPLWQIPEIRRFYGMEHGGGYDSWRKTSVVASPFDFDEAESLRPKGHCVAVRVTSEDPDDGFKPTSGEIQELSFKSKPNMWSYFSVKSGGGIHEFSDSQFGHVFAFGESRSVAIANMVLALKEIQIRGDIRTNVDYTIDLLHASDYRENKIHTGWLDSRIAMRVRAERPPWYLSVVGGALYKASTTSSAVVSDYVGYLEKGQIPPKHISLVHSQVSLNIEGSKYTIDVVRGGSGTYRLRMSNSEVVAEIHTLRDGGLLMQLDGKSHVIYAKEEATGTRLLIDGRTCLLQNDHDPSKLMAETPCKLLRYLVSDNSSIDTDTPYAEVEVMKMCMPLISPASGVIHFKLSEGQAMQAGELIAKLDLDDPSAVRKAKPFRGSFPRLGLPTAISGKVHQRCAATLNAARMILAGYDHKVDEVLQDLLNCLDSPELPFLQWQECFAVLATRLPKDLRNMLELKYKEFEIISKTSLTPDFPAKLLKGILEAHLSSCDEKERGSLERLIEPLMSLVKSYEGGRESHARLIVHSLFEEYLSVEELFNDNMLADVIERMRQQYKKDRLKIVDIVLSHQGIIHKNKLVLRLMEQLVYPNPAAYREKLIRFSALNHTNYSQLALKASQLLEQTKRSELRSNIARSLSELEMFTEAGENMDTPKRKSAISETMENLVSSSLAVEDALVGLFDHSDHTLQRRVVETYIHRLYQPYVVKESVRMQWHQSGVIASWEFLEHFERKNTGPDDHEISEKGIVAKSSKRKRGTMVIIKSLQFLPSIINASLRETNHSHCEYARAPLSGNMMHIAVVGINNQMSLLQDSGDEDQTQERVNKLAKILKEEEVSLTLCSAGVGVISCIIQRDEGRTPMRHSFHWLMEKQYYVEEPLLRHVEPPLSVYLELDKLKGYSNIQYSPSRDRQWHMYSVTDRPVPIKRMFLRSLVRQTTMNDGFLLQQGQDYQLSQTVLSMAFTSKCILRSLMNAMEELELNAHNAAMKPDHAHMFLCILREQQIDDLVPYPRRFEVNAEDEETTVETILEEATQEIHRSVGVRMHALGVCEWEVRLWLVSSGLANGAWRVVVANVTGRTCTVHIYREVEATGRNSLIYHSITKKGPLHGTLINGQYKPLNNLDRKRLAARRSNTTYCYDFPLAFETALELNWASQHSGVRKPCKNRLINVKELVFSNTEGSLGTSLIPVERPAGLNDIGMVAWILEMSTPEFPMGRKLLIVANDVTFKAGSFGPREDAFFLAVTELACTKKLPLIYLAANSGARLGVAEEVKACFKVGWSDEVSPGNDFQYIYLSSEDYARIGSSVIAHEVKLPSGETRWVIDTIVGKEDGLGVENLTGSGAIAGAYSRAYNETFTLTFVSGRSVGIGAYLARLGMRCIQRLDQPIILTGFSTLNKLLGREVYSSHMQLGGPKIMGTNGVVHLTVSDDLEGVSAILNWLSYIPAYVGGPLPVLAPLDPPERTVEYIPENSCDPRAAIAGINDNTGKWLGGIFDKNSFVETLEGWARTVVTGRAKLGGIPIGVVAVETQTVMHVIPADPGQLDSHERVVPQAGQVWFPDSAAKTAQALMDFNREQLPLFIIANWRGFSGGQRDLFEGILQAGSAIVENLRTYRQPVFVYIPMMGELRGGAWVVVDSQINSDYIEMYADETARGNVLEPEGMIEIKFRRKELLECMGRLDQTLINLKANIQDAKRNKAYANIELLQKQIKTREKQLLPVYTQIATKFAELHDTSMRMAAKGVIKSVVEWSGSRSFFYKKLYRRIAESSLVRNIRKASGDILSYKSAMGLIQDWFRKSEIAKGKEEAWTDDQLFFTWKDNVSNYEQKLSELRTQKLLNQLAEIGNSSDLQALPQGLANLLNKVDLSRREELVDAIRKVLG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
813	N6-biotinyllysine	YAEVEVMKMCMPLIS CHHHHHHHHHHHHEE	33.84	-
813	Biotinylation	YAEVEVMKMCMPLIS CHHHHHHHHHHHHEE	33.84	-
1133	Phosphorylation	EAGENMDTPKRKSAI HHCCCCCCHHHHHHH	21.68	-
1143	Phosphorylation	RKSAISETMENLVSS HHHHHHHHHHHHHHC	24.01	19880383
1293	Phosphorylation	QMSLLQDSGDEDQTQ CHHHHHCCCCHHHHH	34.87	-
2304	Phosphorylation	SNYEQKLSELRTQKL CCHHHHHHHHHHHHH	41.44	24243849

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ACC2_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ACC2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ACC2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ACC2_ARATH !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ACC2_ARATH

Related Literatures of Post-Translational Modification