ACBP_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACBP_RAT
• UniProt AC: P11030
• Protein Name: Acyl-CoA-binding protein
• Gene Name: Dbi
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 87
• Subcellular Localization: Endoplasmic reticulum . Golgi apparatus . Golgi localization is dependent on ligand binding.
• Protein Description: Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor..
• Protein Sequence: MSQADFDKAAEEVKRLKTQPTDEEMLFIYSHFKQATVGDVNTDRPGLLDLKGKAKWDSWNKLKGTSKENAMKTYVEKVEELKKKYGI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSQADFDKA ------CCHHHHHHH	33.79	18455725
2	Acetylation	------MSQADFDKA ------CCHHHHHHH	33.79	2803267
8	Succinylation	MSQADFDKAAEEVKR CCHHHHHHHHHHHHH	49.87	-
8	Succinylation	MSQADFDKAAEEVKR CCHHHHHHHHHHHHH	49.87	-
8	Acetylation	MSQADFDKAAEEVKR CCHHHHHHHHHHHHH	49.87	22902405
14	Acetylation	DKAAEEVKRLKTQPT HHHHHHHHHHCCCCC	56.12	22902405
17	Acetylation	AEEVKRLKTQPTDEE HHHHHHHCCCCCCHH	49.50	22902405
17	Succinylation	AEEVKRLKTQPTDEE HHHHHHHCCCCCCHH	49.50	-
17	Succinylation	AEEVKRLKTQPTDEE HHHHHHHCCCCCCHH	49.50	-
29	Phosphorylation	DEEMLFIYSHFKQAT CHHHHHHHHHHCCCC	6.69	22108457
30	Phosphorylation	EEMLFIYSHFKQATV HHHHHHHHHHCCCCC	20.03	25403869
33	Acetylation	LFIYSHFKQATVGDV HHHHHHHCCCCCCCC	33.33	22902405
51	Acetylation	RPGLLDLKGKAKWDS CCCCCCCCCCCCHHC	59.02	25786129
51	Ubiquitination	RPGLLDLKGKAKWDS CCCCCCCCCCCCHHC	59.02	-
53	Acetylation	GLLDLKGKAKWDSWN CCCCCCCCCCHHCHH	45.25	22902405
55	N6-malonyllysine	LDLKGKAKWDSWNKL CCCCCCCCHHCHHHC	55.83	-
55	Malonylation	LDLKGKAKWDSWNKL CCCCCCCCHHCHHHC	55.83	-
55	Succinylation	LDLKGKAKWDSWNKL CCCCCCCCHHCHHHC	55.83	-
55	Acetylation	LDLKGKAKWDSWNKL CCCCCCCCHHCHHHC	55.83	25786129
58	Phosphorylation	KGKAKWDSWNKLKGT CCCCCHHCHHHCCCC	31.28	29779826
61	Acetylation	AKWDSWNKLKGTSKE CCHHCHHHCCCCCHH	45.37	22902405
63	Acetylation	WDSWNKLKGTSKENA HHCHHHCCCCCHHHH	62.85	26302492
67	Acetylation	NKLKGTSKENAMKTY HHCCCCCHHHHHHHH	55.62	22902405
72	Acetylation	TSKENAMKTYVEKVE CCHHHHHHHHHHHHH	34.00	22902405
77	Ubiquitination	AMKTYVEKVEELKKK HHHHHHHHHHHHHHH	44.92	-
77	Succinylation	AMKTYVEKVEELKKK HHHHHHHHHHHHHHH	44.92	-
77	Acetylation	AMKTYVEKVEELKKK HHHHHHHHHHHHHHH	44.92	22902405
77	Succinylation	AMKTYVEKVEELKKK HHHHHHHHHHHHHHH	44.92	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACBP_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACBP_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACBP_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of ACBP_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Acyl-CoA-binding protein in the rat. Purification, bindingcharacteristics, tissue concentrations and amino acid sequence.";
Knudsen J., Hoejrup P., Hansen H.O., Hansen H.F., Roepstorff P.;
Biochem. J. 262:513-519(1989).
Cited for: PROTEIN SEQUENCE OF 2-87, AND ACETYLATION AT SER-2.
PubMed: 2803267