ACBG1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACBG1_RAT
• UniProt AC: Q924N5
• Protein Name: Long-chain-fatty-acid--CoA ligase ACSBG1
• Gene Name: Acsbg1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 721
• Subcellular Localization: Cytoplasm . Cytoplasmic vesicle. Microsome. Endoplasmic reticulum.
• Protein Description: Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids..
• Protein Sequence: MPRSSEAGYCCLSRDSNMPDSRDDQQQGASMGTSPDNSQTSSLIDGRTLSKESPSHGLELSAPEKARAASLDASEEALWTTRADGRVRLRLEPFCTQLPYTVHQMFYEALDKYGNLSALGFKRKDKWERISYYQYYLIARKVAKGFLKLGLERAHSVAILGFNSPEWFFSAVGTVFAGGIVTGIYTTSSPEACQYIAHDCRANVIVVDTQKQLEKILKIWKDLPHLKAVVIYQEPPPKKMANVYTMEELIELGQEVPEEALDAIIDTQQPNQCCVLVYTSGTTGNPKGVMLSQDNITWTARYGSQAGDIQPAEVQQEVVVSYLPLSHIAAQIYDLWTGIQWGAQVCFADPDALKGTLVNTLREVEPTSHMGVPRVWEKIMERIQEVAAQSGFIRRKMLLWAMSVTLEQNLTCPSNDLKPFTSRLADYLVLARVRQALGFAKCQKNFYGAAPMTAETQRFFLGLNIRLYAGYGLSESTGPHFMSSPYNYRLYSSGRVVPGCRVKLVNQDADGIGEICLWGRTIFMGYLNMEDKTHEAIDSEGWLHTGDMGRLDDDGFLYITGRLKELIITAGGENVPPVPIEEAVKMELPIISSAMLIGDQRKFLSMLLTLKCTLNPETSEPTDNLTEQAVEFCQRVGSKASTVSEIVGQKDEAVYQAIHEGIQRVNANAAARPYHIQKWAILERDFSISGGELGPTMKLKRLTVLEKYKDIIDSFYQEQKQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MPRSSEAGYCC ----CCCCCCCCCEE	27.02	27097102
5	Phosphorylation	---MPRSSEAGYCCL ---CCCCCCCCCEEC	32.51	27097102
16	Phosphorylation	YCCLSRDSNMPDSRD CEECCCCCCCCCCCC	33.64	26022182
21	Phosphorylation	RDSNMPDSRDDQQQG CCCCCCCCCCHHHCH	31.57	26022182
30	Phosphorylation	DDQQQGASMGTSPDN CHHHCHHCCCCCCCC	25.27	27097102
33	Phosphorylation	QQGASMGTSPDNSQT HCHHCCCCCCCCCCC	28.57	27097102
34	Phosphorylation	QGASMGTSPDNSQTS CHHCCCCCCCCCCCC	25.24	27097102
38	Phosphorylation	MGTSPDNSQTSSLID CCCCCCCCCCCCCCC	42.06	27097102
40	Phosphorylation	TSPDNSQTSSLIDGR CCCCCCCCCCCCCCE	21.80	27097102
41	Phosphorylation	SPDNSQTSSLIDGRT CCCCCCCCCCCCCEE	18.60	27097102
42	Phosphorylation	PDNSQTSSLIDGRTL CCCCCCCCCCCCEEC	32.50	27097102
48	Phosphorylation	SSLIDGRTLSKESPS CCCCCCEECCCCCCC	40.70	25403869
50	Phosphorylation	LIDGRTLSKESPSHG CCCCEECCCCCCCCC	33.49	30411139
51	Acetylation	IDGRTLSKESPSHGL CCCEECCCCCCCCCC	66.38	22902405
53	Phosphorylation	GRTLSKESPSHGLEL CEECCCCCCCCCCCC	35.12	27097102
55	Phosphorylation	TLSKESPSHGLELSA ECCCCCCCCCCCCCC	39.19	27097102
61	Phosphorylation	PSHGLELSAPEKARA CCCCCCCCCCHHHHH	32.19	27097102
65	Ubiquitination	LELSAPEKARAASLD CCCCCCHHHHHHCCC	41.96	-
70	Phosphorylation	PEKARAASLDASEEA CHHHHHHCCCCCHHH	26.29	29779826
74	Phosphorylation	RAASLDASEEALWTT HHHCCCCCHHHHEEE	35.32	27097102
211	Acetylation	VIVVDTQKQLEKILK EEEECCHHHHHHHHH	59.97	22902405
211	Ubiquitination	VIVVDTQKQLEKILK EEEECCHHHHHHHHH	59.97	-
215	Acetylation	DTQKQLEKILKIWKD CCHHHHHHHHHHHHC	63.03	22902405
218	Acetylation	KQLEKILKIWKDLPH HHHHHHHHHHHCCCC	50.41	22902405
221	Acetylation	EKILKIWKDLPHLKA HHHHHHHHCCCCCEE	53.51	22902405
238	Acetylation	IYQEPPPKKMANVYT EECCCCCHHHCCEEC	62.04	22902405
639	Ubiquitination	FCQRVGSKASTVSEI HHHHHCCCHHCHHHH	40.19	-
650	Acetylation	VSEIVGQKDEAVYQA HHHHHCCCCHHHHHH	52.16	22902405
655	Phosphorylation	GQKDEAVYQAIHEGI CCCCHHHHHHHHHHH	10.16	3430151
674	Phosphorylation	ANAAARPYHIQKWAI CCCCCCCHHHHHHHE	13.15	8315817
678	Acetylation	ARPYHIQKWAILERD CCCHHHHHHHEEEEE	37.68	22902405
709	Acetylation	LTVLEKYKDIIDSFY HHHHHHHHHHHHHHH	54.22	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACBG1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACBG1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACBG1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of ACBG1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.