ACADL_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACADL_RAT
• UniProt AC: P15650
• Protein Name: Long-chain specific acyl-CoA dehydrogenase, mitochondrial
• Gene Name: Acadl
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 430
• Subcellular Localization: Mitochondrion matrix.
• Protein Sequence: MAARLLLRSLRVLSARSATLPPPSARCSHSGAEARLETPSAKKLTDIGIRRIFSSEHDIFRESVRKFFQEEVIPYHEEWEKAGEVSRELWEKAGKQGLLGINIAEKHGGIGGDLLSTAVTWEEQAYSNCTGPGFSLHSDIVMPYIANYGTKEQIEQFIPQMTAGKCIGAIAMTEPGAGSDLQGVRTNAKRSGSDWILNGSKVFITNGWLSDLVIVVAVTNREARSPAHGISLFLVENGMKGFIKGKKLHKMGMKAQDTAELFFEDVRLPASALLGEENKGFYYLMQELPQERLLIADLAISACEFMFEETRNYVRQRKAFGKTVAHIQTVQHKLAELKTNICVTRAFVDSCLQLHETKRLDSASASMAKYWASELQNTVAYQCVQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEIMKELIARQIVSDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	Acetylation	RLETPSAKKLTDIGI CCCCCCCCHHCHHCH	53.29	22902405
43	Acetylation	LETPSAKKLTDIGIR CCCCCCCHHCHHCHH	57.23	22902405
45	O-linked_Glycosylation	TPSAKKLTDIGIRRI CCCCCHHCHHCHHHH	34.16	27213235
45	Phosphorylation	TPSAKKLTDIGIRRI CCCCCHHCHHCHHHH	34.16	29779826
54	O-linked_Glycosylation	IGIRRIFSSEHDIFR HCHHHHHCCCHHHHH	32.23	27213235
54	Phosphorylation	IGIRRIFSSEHDIFR HCHHHHHCCCHHHHH	32.23	27097102
55	Phosphorylation	GIRRIFSSEHDIFRE CHHHHHCCCHHHHHH	28.35	21738781
63	Phosphorylation	EHDIFRESVRKFFQE CHHHHHHHHHHHHHH	23.98	25575281
66	Succinylation	IFRESVRKFFQEEVI HHHHHHHHHHHHCCC	48.66	26843850
66	Succinylation	IFRESVRKFFQEEVI HHHHHHHHHHHHCCC	48.66	-
66	Acetylation	IFRESVRKFFQEEVI HHHHHHHHHHHHCCC	48.66	22902405
81	Succinylation	PYHEEWEKAGEVSRE CCHHHHHHHHHHHHH	63.87	-
81	Succinylation	PYHEEWEKAGEVSRE CCHHHHHHHHHHHHH	63.87	-
81	Acetylation	PYHEEWEKAGEVSRE CCHHHHHHHHHHHHH	63.87	22902405
92	Succinylation	VSRELWEKAGKQGLL HHHHHHHHHHHCCCE	51.35	26843850
92	Acetylation	VSRELWEKAGKQGLL HHHHHHHHHHHCCCE	51.35	22902405
95	Succinylation	ELWEKAGKQGLLGIN HHHHHHHHCCCEEEE	46.16	26843850
95	Acetylation	ELWEKAGKQGLLGIN HHHHHHHHCCCEEEE	46.16	22902405
151	Acetylation	YIANYGTKEQIEQFI HHHCCCCHHHHHHHH	43.17	26302492
165	Acetylation	IPQMTAGKCIGAIAM HHHCCCCCEEEEEEE	21.88	22902405
165	Succinylation	IPQMTAGKCIGAIAM HHHCCCCCEEEEEEE	21.88	-
165	Succinylation	IPQMTAGKCIGAIAM HHHCCCCCEEEEEEE	21.88	-
179	Phosphorylation	MTEPGAGSDLQGVRT ECCCCCCCCCCCCCC	34.31	25575281
191	Phosphorylation	VRTNAKRSGSDWILN CCCCCCCCCCCEEEC	41.78	23991683
193	Phosphorylation	TNAKRSGSDWILNGS CCCCCCCCCEEECCC	30.90	23991683
225	Phosphorylation	VTNREARSPAHGISL ECCCCCCCCCCCEEE	33.22	23991683
240	Acetylation	FLVENGMKGFIKGKK EEEECCCCCEECCHH	52.66	22902405
240	Succinylation	FLVENGMKGFIKGKK EEEECCCCCEECCHH	52.66	-
240	Succinylation	FLVENGMKGFIKGKK EEEECCCCCEECCHH	52.66	-
254	Succinylation	KLHKMGMKAQDTAEL HHHHCCCCHHHHHHH	36.85	-
254	Acetylation	KLHKMGMKAQDTAEL HHHHCCCCHHHHHHH	36.85	22902405
254	Succinylation	KLHKMGMKAQDTAEL HHHHCCCCHHHHHHH	36.85	-
271	Phosphorylation	EDVRLPASALLGEEN HCCCCCHHHHHCCCC	19.94	30181290
279	Succinylation	ALLGEENKGFYYLMQ HHHCCCCCHHHHHHH	54.39	-
279	Succinylation	ALLGEENKGFYYLMQ HHHCCCCCHHHHHHH	54.39	-
279	Acetylation	ALLGEENKGFYYLMQ HHHCCCCCHHHHHHH	54.39	22902405
282	Phosphorylation	GEENKGFYYLMQELP CCCCCHHHHHHHHCC	12.35	23991683
283	Phosphorylation	EENKGFYYLMQELPQ CCCCHHHHHHHHCCH	8.08	23991683
318	Acetylation	RNYVRQRKAFGKTVA HHHHHHHHHHCCHHH	39.46	22902405
322	Acetylation	RQRKAFGKTVAHIQT HHHHHHCCHHHHHHH	33.11	22902405
322	Succinylation	RQRKAFGKTVAHIQT HHHHHHCCHHHHHHH	33.11	-
322	Succinylation	RQRKAFGKTVAHIQT HHHHHHCCHHHHHHH	33.11	-
333	Acetylation	HIQTVQHKLAELKTN HHHHHHHHHHHCCCC	32.09	22902405
350	Phosphorylation	VTRAFVDSCLQLHET HHHHHHHHHHHHHHH	16.07	25575281
358	Acetylation	CLQLHETKRLDSASA HHHHHHHCCCCHHCH	48.23	22902405
362	Phosphorylation	HETKRLDSASASMAK HHHCCCCHHCHHHHH	28.81	29779826
364	Phosphorylation	TKRLDSASASMAKYW HCCCCHHCHHHHHHH	25.48	30181290
364	O-linked_Glycosylation	TKRLDSASASMAKYW HCCCCHHCHHHHHHH	25.48	27213235
366	Phosphorylation	RLDSASASMAKYWAS CCCHHCHHHHHHHHH	19.44	30181290
419	Acetylation	GGTNEIMKELIARQI CCHHHHHHHHHHHHH	55.84	22902405
428	Phosphorylation	LIARQIVSDS----- HHHHHHHCCC-----	33.49	24945867
430	Phosphorylation	ARQIVSDS------- HHHHHCCC-------	34.32	24945867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACADL_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
318	K	Acetylation	Acetylation at Lys-318 and Lys-322 in proximity of the cofactor-binding sites strongly reduces catalytic activity.	-
322	K	Acetylation	Acetylation at Lys-318 and Lys-322 in proximity of the cofactor-binding sites strongly reduces catalytic activity.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACADL_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of ACADL_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.