dbPTM

ACA2_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ACA2_ARATH
UniProt AC	O81108
Protein Name	Calcium-transporting ATPase 2, plasma membrane-type
Gene Name	ACA2
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	1014
Subcellular Localization	Endoplasmic reticulum membrane Multi-pass membrane protein.
Protein Description	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the endoplasmic reticulum..
Protein Sequence	MESYLNENFDVKAKHSSEEVLEKWRNLCGVVKNPKRRFRFTANLSKRYEAAAMRRTNQEKLRIAVLVSKAAFQFISGVSPSDYTVPEDVKAAGFEICADELGSIVESHDVKKLKFHGGVDGLAGKLKASPTDGLSTEAAQLSQRQELFGINKFAESEMRGFWVFVWEALQDMTLMILGVCAFVSLIVGIATEGWPKGSHDGLGIAASILLVVFVTATSDYRQSLQFRDLDKEKKKITVQVTRNGFRQKLSIYDLLPGDIVHLAIGDQVPADGLFLSGFSVVIDESSLTGESEPVMVNAQNPFLMSGTKVQDGSCKMMITTVGMRTQWGKLMATLTEGGDDETPLQVKLNGVATIIGKIGLFFAVVTFAVLVQGMFMRKLSTGTHWVWSGDEALELLEYFAIAVTIVVVAVPEGLPLAVTLSLAFAMKKMMNDKALVRHLAACETMGSATTICSDKTGTLTTNHMTVVKSCICMNVQDVANKGSSLQSEIPESAVKLLIQSIFNNTGGEVVVNKHGKTELLGTPTETAILELGLSLGGKFQEERKSYKVIKVEPFNSTKKRMGVVIELPEGGRMRAHTKGASEIVLAACDKVVNSSGEVVPLDEESIKYLNVTINEFANEALRTLCLAYMDIEGGFSPDDAIPASGFTCVGIVGIKDPVRPGVKESVELCRRAGITVRMVTGDNINTAKAIARECGILTDDGIAIEGPVFREKNQEELLELIPKIQVMARSSPMDKHTLVKQLRTTFDEVVAVTGDGTNDAPALHEADIGLAMGIAGTEVAKESADVIILDDNFSTIVTVAKWGRSVYINIQKFVQFQLTVNVVALVVNFSSACLTGSAPLTAVQLLWVNMIMDTLGALALATEPPNDELMKRLPVGRRGNFITNAMWRNILGQAVYQFIVIWILQAKGKAMFGLDGPDSTLMLNTLIFNCFVFCQVFNEISSREMEEIDVFKGILDNYVFVVVIGATVFFQIIIIEFLGTFASTTPLTITQWIFSIFIGFLGMPIAAGLKTIPV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MESYLNEN -------CCCHHCCC	35.61	22223895
41	Phosphorylation	PKRRFRFTANLSKRY CCCCEEEEECHHHHH	15.47	25561503
45	Phosphorylation	FRFTANLSKRYEAAA EEEEECHHHHHHHHH	18.20	10823962
581	Phosphorylation	RAHTKGASEIVLAAC EEECCCCCHHHHHHC	36.20	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
45	S	Phosphorylation	Kinase	CPK1	Q06850	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ACA2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ACA2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NAC89_ARATH	NAC089	physical	21798944
GDU4_ARATH	GDU4	physical	22737156
CNG10_ARATH	CNGC10	physical	22737156
UPS1_ARATH	UPS1	physical	22737156

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ACA2_ARATH

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A calcium-dependent protein kinase can inhibit a calmodulin-stimulated Ca2+ pump (ACA2) located in the endoplasmic reticulum ofArabidopsis."; Hwang I., Sze H., Harper J.F.; Proc. Natl. Acad. Sci. U.S.A. 97:6224-6229(2000). Cited for: PHOSPHORYLATION AT SER-45 BY CPK1.	10823962 [Abstract]