ABRX1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ABRX1_MOUSE
• UniProt AC: Q8BPZ8
• Protein Name: BRCA1-A complex subunit Abraxas 1 {ECO:0000312|MGI:MGI:1917931}
• Gene Name: Abraxas1 {ECO:0000312|MGI:MGI:1917931}
• Organism: Mus musculus (Mouse).
• Sequence Length: 407
• Subcellular Localization: Nucleus . Localizes at sites of DNA damage at double-strand breaks (DSBs).
• Protein Description: Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX..
• Protein Sequence: MEGESTLGVLSGFVLGALTFHHLNTDSDTEGFLLGEMKGEAKNSITDSQMDNVKVVYTIDIQKYIPCYRLFSFYNSLGEVNEHALKKVLSNVRKTVVGWYKFRRHSDQIMTFREQLLHRNLQTHLSSPELVFLLLTPSITTESCSTHCLEHALYKPQRGLFHRVPLVVTNLGMSDQLGYKTEPASCTSTVFSRAVRTHSSQFFNEDGSLKEVHKINEMYAAVQEELKSICQKVEQSEREVEKLLMDVNQLKEVRRTQQARATGAGEKNVQRNPQENILLCQALRTFFPESEVLHSCVISLKNRHISPSGCNVNHHVDVVDQLTLMVEYVYSPEASPVPTAQLRKRKALDTHDQGSVKRPRLLETESRPSVAASRSRHQDKASSSSLDIDIEMGSPEDDADYPRSPTF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Phosphorylation	MKGEAKNSITDSQMD CCCCCCCCCCHHHCC		25159016
46	Phosphorylation	GEAKNSITDSQMDNV CCCCCCCCHHHCCCE		29472430
48	Phosphorylation	AKNSITDSQMDNVKV CCCCCCHHHCCCEEE		26824392
136	Phosphorylation	ELVFLLLTPSITTES HHEEEEECCCCCCCH		51457579
138	Phosphorylation	VFLLLTPSITTESCS EEEEECCCCCCCHHH		51457585
355	Phosphorylation	LDTHDQGSVKRPRLL CCCCCCCCCCCCCCC		25266776
366	Phosphorylation	PRLLETESRPSVAAS CCCCCCCCCCCHHHH		29514104
369	Phosphorylation	LETESRPSVAASRSR CCCCCCCCHHHHHHH		29514104
384	Phosphorylation	HQDKASSSSLDIDIE CCCCCCCCCCCEEEC		-
385	Phosphorylation	QDKASSSSLDIDIEM CCCCCCCCCCEEECC		-
394	Phosphorylation	DIDIEMGSPEDDADY CEEECCCCCCCCCCC		19060867
404	Phosphorylation	DDADYPRSPTF---- CCCCCCCCCCC----		19060867
406	Phosphorylation	ADYPRSPTF------ CCCCCCCCC------		21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ABRX1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
404	S	Phosphorylation	Phosphorylation of Ser-404 of the pSXXF motif by ATM or ATR constitutes a specific recognition motif for the BRCT domain of BRCA1.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ABRX1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ABRX1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.