ABCD2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ABCD2_HUMAN
• UniProt AC: Q9UBJ2
• Protein Name: ATP-binding cassette sub-family D member 2
• Gene Name: ABCD2
• Organism: Homo sapiens (Human).
• Sequence Length: 740
• Subcellular Localization: Peroxisome membrane; Multi-pass membrane protein.
• Protein Description: Probable transporter..
• Protein Sequence: MTHMLNAAADRVKWTRSSAAKRAACLVAAAYALKTLYPIIGKRLKQSGHGKKKAAAYPAAENTEILHCTETICEKPSPGVNADFFKQLLELRKILFPKLVTTETGWLCLHSVALISRTFLSIYVAGLDGKIVKSIVEKKPRTFIIKLIKWLMIAIPATFVNSAIRYLECKLALAFRTRLVDHAYETYFTNQTYYKVINMDGRLANPDQSLTEDIMMFSQSVAHLYSNLTKPILDVMLTSYTLIQTATSRGASPIGPTLLAGLVVYATAKVLKACSPKFGKLVAEEAHRKGYLRYVHSRIIANVEEIAFYRGHKVEMKQLQKSYKALADQMNLILSKRLWYIMIEQFLMKYVWSSSGLIMVAIPIITATGFADGEDGQKQVMVSERTEAFTTARNLLASGADAIERIMSSYKEVTELAGYTARVYNMFWVFDEVKRGIYKRTAVIQESESHSKNGAKVELPLSDTLAIKGKVIDVDHGIICENVPIITPAGEVVASRLNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEGVLYKPPPQHMFYIPQRPYMSLGSLRDQVIYPDSVDDMHDKGYTDQDLERILHNVHLYHIVQREGGWDAVMDWKDVLSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAKGAGISLLSITHRPSLWKYHTHLLQFDGEGGWRFEQLDTAIRLTLSEEKQKLESQLAGIPKMQQRLNELCKILGEDSVLKTIKNEDETS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
71	Phosphorylation	EILHCTETICEKPSP EEEEEECCCCCCCCC	16.87	68741449
146	Acetylation	KPRTFIIKLIKWLMI CCCCHHHHHHHHHHH	39.07	7290115
149	Acetylation	TFIIKLIKWLMIAIP CHHHHHHHHHHHHCH	44.72	7290127
170	Acetylation	AIRYLECKLALAFRT HHHHHHHHHHHHHHH	27.67	7290139
186	Phosphorylation	LVDHAYETYFTNQTY HHCCHHHHHCCCCEE	15.97	68734027
190	N-linked_Glycosylation	AYETYFTNQTYYKVI HHHHHCCCCEEEEEE	23.46	UniProtKB CARBOHYD
227	N-linked_Glycosylation	SVAHLYSNLTKPILD HHHHHHHCCCHHHHH	37.87	UniProtKB CARBOHYD
378	Acetylation	ADGEDGQKQVMVSER CCCCCCCEEEEEECH	50.84	19413330
390	Phosphorylation	SERTEAFTTARNLLA ECHHHHHHHHHHHHH	26.96	72550295
391	Phosphorylation	ERTEAFTTARNLLAS CHHHHHHHHHHHHHH	19.71	19413330
410	Phosphorylation	IERIMSSYKEVTELA HHHHHHHCHHHHHHH	12.12	72550291
411	Ubiquitination	ERIMSSYKEVTELAG HHHHHHCHHHHHHHC	47.89	29901268
414	Phosphorylation	MSSYKEVTELAGYTA HHHCHHHHHHHCHHH	26.77	20068231
419	Phosphorylation	EVTELAGYTARVYNM HHHHHHCHHHHHHHH	7.51	20068231
420	Phosphorylation	VTELAGYTARVYNMF HHHHHCHHHHHHHHH	13.68	20068231
424	Phosphorylation	AGYTARVYNMFWVFD HCHHHHHHHHHHHHH	8.71	28509920
447	Phosphorylation	RTAVIQESESHSKNG EEEEEECCHHHCCCC	28.20	22210691
449	Phosphorylation	AVIQESESHSKNGAK EEEECCHHHCCCCCE	42.19	23403867
451	Phosphorylation	IQESESHSKNGAKVE EECCHHHCCCCCEEE	36.78	23403867
456	Ubiquitination	SHSKNGAKVELPLSD HHCCCCCEEEEECCC	37.33	32142685
462	Phosphorylation	AKVELPLSDTLAIKG CEEEEECCCCEEECC	26.98	22210691
517	Ubiquitination	TGPNGCGKSSLFRIL ECCCCCCHHHHHHHH	40.73	21963094
519	Phosphorylation	PNGCGKSSLFRILSG CCCCCHHHHHHHHHC	34.71	24719451
556	Phosphorylation	RPYMSLGSLRDQVIY CCCCCCCCCCCCEEC	26.06	24719451
614	Ubiquitination	DVLSGGEKQRMGMAR HHHCCCHHHHHCCHH	46.62	29901268
670	Phosphorylation	HRPSLWKYHTHLLQF CCCCHHHEEEEEEEE	10.60	7331161
705	Phosphorylation	EEKQKLESQLAGIPK HHHHHHHHHHCCHHH	40.71	29978859

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ABCD2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ABCD2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ABCD2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ABCD2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.