ABCB5_HUMAN - dbPTM
ABCB5_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ABCB5_HUMAN
UniProt AC Q2M3G0
Protein Name ATP-binding cassette sub-family B member 5
Gene Name ABCB5
Organism Homo sapiens (Human).
Sequence Length 1257
Subcellular Localization Cell membrane
Multi-pass membrane protein .
Protein Description Drug efflux transporter present in a number of stem cells that acts as a regulator of cellular differentiation. Able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair..
Protein Sequence MENSERAEEMQENYQRNGTAEEQPKLRKEAVGSIEIFRFADGLDITLMILGILASLVNGACLPLMPLVLGEMSDNLISGCLVQTNTTNYQNCTQSQEKLNEDMTLLTLYYVGIGVAALIFGYIQISLWIITAARQTKRIRKQFFHSVLAQDIGWFDSCDIGELNTRMTDDIDKISDGIGDKIALLFQNMSTFSIGLAVGLVKGWKLTLVTLSTSPLIMASAAACSRMVISLTSKELSAYSKAGAVAEEVLSSIRTVIAFRAQEKELQRYTQNLKDAKDFGIKRTIASKVSLGAVYFFMNGTYGLAFWYGTSLILNGEPGYTIGTVLAVFFSVIHSSYCIGAAVPHFETFAIARGAAFHIFQVIDKKPSIDNFSTAGYKPESIEGTVEFKNVSFNYPSRPSIKILKGLNLRIKSGETVALVGLNGSGKSTVVQLLQRLYDPDDGFIMVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDIKKADEQMESMTYSTERKTNSLPLHSVKSIKSDFIDKAEESTQSKEISLPEVSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDAEIYSMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNAQSVQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
14PhosphorylationAEEMQENYQRNGTAE
HHHHHHHHHHCCCHH		20.0729978859
17N-linked_GlycosylationMQENYQRNGTAEEQP
HHHHHHHCCCHHHCH		30.50UniProtKB CARBOHYD
85N-linked_GlycosylationSGCLVQTNTTNYQNC
HHCEEECCCCCCCCC		44.83UniProtKB CARBOHYD
91N-linked_GlycosylationTNTTNYQNCTQSQEK
CCCCCCCCCCCCHHH		5.01UniProtKB CARBOHYD
251PhosphorylationAVAEEVLSSIRTVIA
HHHHHHHHHHHHHHH		18.2624719451
252PhosphorylationVAEEVLSSIRTVIAF
HHHHHHHHHHHHHHH		2.9525954137
371N-linked_GlycosylationDKKPSIDNFSTAGYK
CCCCCCCCCCCCCCC		3.25UniProtKB CARBOHYD
390N-linked_GlycosylationEGTVEFKNVSFNYPS
ECEEEEEEECCCCCC		3.84UniProtKB CARBOHYD
423N-linked_GlycosylationTVALVGLNGSGKSTV
EEEEEECCCCCHHHH		71.97UniProtKB CARBOHYD
460PhosphorylationRALNVRHYRDHIGVV
EEECCCCCHHCEEEC		37.4968737983
477PhosphorylationEPVLFGTTISNNIKY
CCEEECEEECCCCCC		16.6368737989
479PhosphorylationVLFGTTISNNIKYGR
EEECEEECCCCCCCC		1.9168737995
561PhosphorylationALDSESKSAVQAALE
CCCCCCHHHHHHHHH		61.4550558519
668PhosphorylationKAEESTQSKEISLPE
HHHHHHCCCCCCCCH		22.6350558527
672PhosphorylationSTQSKEISLPEVSLL
HHCCCCCCCCHHHHH		31.0650558535
677PhosphorylationEISLPEVSLLKILKL
CCCCCHHHHHHHHHH		6.6224719451
765PhosphorylationGRAGEILTMRLRHLA
CCHHHHHHHHHHHHH		2.1126074081
778PhosphorylationLAFKAMLYQDIAWFD
HHHHHHHHHHHHHCC		1.7526074081
789N-linked_GlycosylationAWFDEKENSTGGLTT
HHCCCCCCCCCCCEE		58.02UniProtKB CARBOHYD
819N-linked_GlycosylationRIGVLTQNATNMGLS
CEEEECCCCCCCCHH		UniProtKB CARBOHYD
910N-linked_GlycosylationMLQTQHRNTSKKAQI
HHHHHCCCCCCHHHH		UniProtKB CARBOHYD
982AcetylationAPEYSKAKSGAAHLF
CCCHHHHHCCHHHHH		7963379
994AcetylationHLFALLEKKPNIDSR
HHHHHHHCCCCCCCC		7963387
1051PhosphorylationKTVAFVGSSGCGKST
CEEEEECCCCCCHHH		22468782
1052PhosphorylationTVAFVGSSGCGKSTS
EEEEECCCCCCHHHH		22468782
1104N-linked_GlycosylationPQEPVLFNCSIAENI
CCCCEEEEEEECCCC		UniProtKB CARBOHYD
1145PhosphorylationIEGLPEKYNTQVGLK
HCCCCHHHCCCCCCC		29396449
1147PhosphorylationGLPEKYNTQVGLKGA
CCCHHHCCCCCCCCC		29396449
1188N-linked_GlycosylationEATSALDNDSEKVVQ
CHHHCCCCCHHHHHH		UniProtKB CARBOHYD
1200AcetylationVVQHALDKARTGRTC
HHHHHHHHHCCCCEE		7378615
1236PhosphorylationGKIKEQGTHQELLRN
CEECCCCCHHHHHHC		24719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ABCB5_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ABCB5_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ABCB5_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ABCB5_HUMAN

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Related Literatures of Post-Translational Modification

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