ABCA2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ABCA2_RAT
• UniProt AC: Q9ESR9
• Protein Name: ATP-binding cassette sub-family A member 2
• Gene Name: Abca2 {ECO:0000312|RGD:620238}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 2434
• Subcellular Localization: Endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Forms discrete, punctate intracellular vesicles..
• Protein Description: Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development..
• Protein Sequence: MGFLHQLQLLLWKNVTLKRRSPWVLAFEIFIPLVLFFILLGLRQKKPTISVKEAFYTAAPLTSAGILPVMQSLCPDGQRDEFGFLQYANSTVTQLLERLNRVVEESNLFDPERPSLGSELEALHQRLEALSSGPGTWESHSARPAVSSFSLDSVARDKRELWRFLMQNLSLPNSTAQALLAARVDPSEVYRLLFGPLPDLDGKLGFLRKQEPWSHLGSNPLFQMEELLLAPALLEQLTCAPGSGELGRILTMPEGHQVDLQGYRDAVCSGQATARAQHFSDLATELRNQLDIAKIAQQLGFNVPNGSDPQPQAPSPQSLQALLGDLLDVQKVLQDVDVLSALALLLPQGACAGRAPAPQAGSPSGPANSTGVGANTGPNTTVEEGTQSPVTPASPDTLQGQCSAFVQLWAGLQPILCGNNRTIEPEALRRGNMSSLGFTSKEQRNLGLLVHLMTSNPKILYAPAGSEADHVILKANETFAFVGNVTHYAQVWLNISAEIRSFLEQGRLQQHLHWLQQYVADLRLHPEAMNLSLDELPPALRLDYFSLPNGTALLQQLDTIDNAACGWIQFMSKVSVDIFKGFPDEESIVNYTLNQAYQDNVTVFASVIFQTRKDGSLPPHVHYKIRQNSSFTEKTNEIRRAYWRPGPNTGGRFYFLYGFVWIQDMIERAIINTFVGHDVVEPGNYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMHSHVLIIWLFLAVYAVATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLMSTTAFGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLMVDTVVYGVLTWYIEAVHPGMYGLPRPWYFPLQKSYWLGSGRTETWEWSWPWAHAPRLSVMEEDQACAMESRHFEETRGMEEEPTHLPLVVCVDKLTKVYKNDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDQLTVEEHLWFYSRLKSMAQEEIRKEMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGAYGDGYRLTLVKRPAEPGTSQEPGMASSPSGRPQLSNCSEMQVSQFIRKHVASSLLVSDTSTELSYILPSEAVKKGAFERLFQQLEHSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADVKESRKDALPGAEGLTAVESQAGNLARCSELAQSQASLQSASSVGSARGDEGAGYTDGYGDYRPLFDNLQDPDSVSLQEAEMEALARVGQGSRKLEGWWLKMRQFHGLLVKRFHCARRNSKALCSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQYHNYTQPRGNFIPYANEERREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPANGSLGPMLNLSSGESRLLAARFFDSMCLESFTQGLPLSNFVPPPPSPAPSDSPLSPDEDSLLAWNTSLPPTAGPETWTWAPSLPRLVHEPVRCTCSAQGTGFSCPSSVGGHPPQMRVVTGDILTDITGHNVSEYLLFTSDRFRLHRYGAITFGNIQKSIPAPIGTRTPLMVRKIAVRRVAQVLYNNKGYHSMPTYLNSLNNAILRANLPKSKGNPAAYGITVTNHPMNKTSASLSLDYLLQGTDVVIAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPVIYWLANYVWDMLNYLVPATCCIIILFVFDLPAYTSPTNFPAVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITATVATFLLQLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGLMEIAYNEYINEYYAKIGQFDKMKSPFEWDIVTRGLVAMTVEGFVGFFLTIMCQYNFLRQPQRLPVSTKPVEDDVDVASERQRVLRGDADNDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSVLKDLLQVQQSLGYCPQFDALFDELTAREHLQLYTRLRGIPWKDEAQVVRWALEKLELTKCADKPAGSYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSMEECEAVCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQNVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHISLAQVFSKMEHVVGVLGIEDYSVSQTTLDNVFVNFAKKQSDNVEQQEAEPSTLPSPLGLLSLLRPRPAPTELRALVADEPEDLDTEDEGLISFEEERAQLSFNTDTLC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	N-linked_Glycosylation	LQLLLWKNVTLKRRS HHHHHHCCCCCCCCC	22.03	-
89	N-linked_Glycosylation	FGFLQYANSTVTQLL CCHHHHHCHHHHHHH	33.02	-
168	N-linked_Glycosylation	LWRFLMQNLSLPNST HHHHHHHCCCCCCHH	20.03	-
173	N-linked_Glycosylation	MQNLSLPNSTAQALL HHCCCCCCHHHHHHH	58.23	-
271	Methylation	RDAVCSGQATARAQH HHHHHHCHHHHHHHH	21.17	-
305	N-linked_Glycosylation	QLGFNVPNGSDPQPQ HHCCCCCCCCCCCCC	59.32	-
368	N-linked_Glycosylation	GSPSGPANSTGVGAN CCCCCCCCCCCCCCC	43.15	-
379	N-linked_Glycosylation	VGANTGPNTTVEEGT CCCCCCCCCCCCCCC	50.13	-
420	N-linked_Glycosylation	QPILCGNNRTIEPEA CEEECCCCCCCCHHH	27.96	-
432	N-linked_Glycosylation	PEALRRGNMSSLGFT HHHHHCCCCHHCCCC	25.92	24090084
476	N-linked_Glycosylation	DHVILKANETFAFVG CEEEEECCCCEEEEC	47.45	-
484	N-linked_Glycosylation	ETFAFVGNVTHYAQV CCEEEECCCHHEEEH	30.16	-
494	N-linked_Glycosylation	HYAQVWLNISAEIRS HEEEHHHHHHHHHHH	15.51	-
530	N-linked_Glycosylation	RLHPEAMNLSLDELP CCCHHHHCCCHHHCC	33.26	-
549	N-linked_Glycosylation	LDYFSLPNGTALLQQ CEEEECCCHHHHHHH	66.78	-
590	N-linked_Glycosylation	PDEESIVNYTLNQAY CCHHHHHHHCCCHHH	23.54	-
600	N-linked_Glycosylation	LNQAYQDNVTVFASV CCHHHHCCCEEEEEE	18.81	-
628	N-linked_Glycosylation	VHYKIRQNSSFTEKT EEEEECCCCCCCHHC	29.76	-
851	Phosphorylation	AFEKCIASLMSTTAF HHHHHHHHHHHHHCC	12.51	22276854
862	Phosphorylation	TTAFGLGSKYFALYE HHCCCCCCHHEEEEE	29.26	22276854
1238	Phosphorylation	QEPGMASSPSGRPQL CCCCCCCCCCCCCCC	17.34	-
1247	N-linked_Glycosylation	SGRPQLSNCSEMQVS CCCCCCCCCCHHHHH	41.76	-
1322	Phosphorylation	EEVFLKVSEEDQSLE HHHHHHHCHHHHHHC	33.41	28551015
1327	Phosphorylation	KVSEEDQSLENSEAD HHCHHHHHHCCCHHH	50.39	23712012
1331	Phosphorylation	EDQSLENSEADVKES HHHHHCCCHHHHHHH	25.45	23712012
1336	Ubiquitination	ENSEADVKESRKDAL CCCHHHHHHHHHHHC	50.98	-
1340	Ubiquitination	ADVKESRKDALPGAE HHHHHHHHHHCCCCC	57.54	-
1354	Phosphorylation	EGLTAVESQAGNLAR CCHHHHHHHCCCHHH	20.80	23984901
1371	Phosphorylation	ELAQSQASLQSASSV HHHHHHHHHHHHHHC	21.21	27097102
1374	Phosphorylation	QSQASLQSASSVGSA HHHHHHHHHHHCCCC	35.10	27097102
1376	Phosphorylation	QASLQSASSVGSARG HHHHHHHHHCCCCCC	30.70	27097102
1377	Phosphorylation	ASLQSASSVGSARGD HHHHHHHHCCCCCCC	30.16	27097102
1380	Phosphorylation	QSASSVGSARGDEGA HHHHHCCCCCCCCCC	16.79	27097102
1410	Phosphorylation	LQDPDSVSLQEAEME CCCCCCCCHHHHHHH	28.43	21630457
1496	N-linked_Glycosylation	LSPSQYHNYTQPRGN CCHHHCCCCCCCCCC	36.29	-
1549	N-linked_Glycosylation	CVLKSPANGSLGPML EEEECCCCCCCCCCE	43.93	-
1557	N-linked_Glycosylation	GSLGPMLNLSSGESR CCCCCCEECCCHHHH	31.46	-
1613	N-linked_Glycosylation	EDSLLAWNTSLPPTA CCCCEEEECCCCCCC	17.74	-
1678	N-linked_Glycosylation	LTDITGHNVSEYLLF HHHCCCCCHHHEEEE	40.11	-
1776	N-linked_Glycosylation	TVTNHPMNKTSASLS EECCCCCCCCCCHHC	49.24	-
2026	Ubiquitination	QRLPVSTKPVEDDVD CCCCCCCCCCCCCCC	39.29	-
2055	N-linked_Glycosylation	NDMVKIENLTKVYKS CCCEEEHHHHHHHHH	57.39	-
2377	Phosphorylation	EQQEAEPSTLPSPLG HHHCCCCCCCCCCCH	33.80	27097102
2378	Phosphorylation	QQEAEPSTLPSPLGL HHCCCCCCCCCCCHH	54.10	27097102
2381	Phosphorylation	AEPSTLPSPLGLLSL CCCCCCCCCCHHHHH	35.55	27097102
2387	Phosphorylation	PSPLGLLSLLRPRPA CCCCHHHHHHCCCCC	30.33	27097102
2411	Phosphorylation	DEPEDLDTEDEGLIS CCCCCCCCCCCCCCC	53.27	29779826
2418	Phosphorylation	TEDEGLISFEEERAQ CCCCCCCCHHHHHHH	31.48	21630457
2427	Phosphorylation	EEERAQLSFNTDTLC HHHHHHHHCCCCCCC	12.36	27097102
2430	Phosphorylation	RAQLSFNTDTLC--- HHHHHCCCCCCC---	28.49	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ABCA2_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
271	Q	Methylation	Methylated at Gln-271 by N6AMT1.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ABCA2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of ABCA2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.