AB25B_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AB25B_ARATH
• UniProt AC: Q9LVM1
• Protein Name: ABC transporter B family member 25, mitochondrial
• Gene Name: ABCB25
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 728
• Subcellular Localization: Mitochondrion inner membrane ; Multi-pass membrane protein .
• Protein Description: Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins. Not required for mitochondrial and plastid Fe-S enzymes. Probably involved in the export of cyclic pyranopterin monophosphate (cPMP) from mitochondria into the cytosol. Mediates glutathione-dependent resistance to heavy metals such as cadmium and lead, as well as their transport from roots to leaves. Regulates nonprotein thiols (NPSH) and the cellular level of glutathione (GSH)..
• Protein Sequence: MSRGSRFVRAPGLLLCRVNLQPQPKIPSFSYSLRSDYRLHNGFSNYIRRNSIRTSPVINAFLSDNSPSPSPSPSPIRFVQRSSMLNGRLFSTSTPNPDQTTTKTKEIKTTSSDSDSAMADMKILRTLAGYLWMRDNPEFRFRVIAALGFLVGAKVLNVQVPFLFKLAVDWLASATGTGASLTTFAATNPTLLTVFATPAAVLIGYGIARTGSSAFNELRTAVFSKVALRTIRSVSRKVFSHLHDLDLRYHLSRETGGLNRIIDRGSRAINFILSAMVFNVVPTILEISMVSGILAYKFGAAFAWITSLSVGSYIVFTLAVTQWRTKFRKAMNKADNDASTRAIDSLINYETVKYFNNEGYEAEKYDQFLKKYEDAALQTQRSLAFLNFGQSIIFSTALSTAMVLCSQGIMNGQMTVGDLVMVNGLLFQLSLPLNFLGSVYRETIQSLVDMKSMFQLLEEKSDITNTSDAKPLVLKGGNIEFENVHFSYLPERKILDGISFVVPAGKSVAIVGTSGSGKSTILRMLFRFFDTDSGNIRIDGQDIKEVRLDSLRSSIGVVPQDTVLFNDTIFHNIHYGRLSATEEEVYEAARRAAIHETISNFPDKYSTIVGERGLKLSGGEKQRVALARTFLKSPAILLCDEATSALDSTTEAEILNALKALASNRTSIFIAHRLTTAMQCDEIVVLENGKVVEQGPHDELLGKSGRYAQLWTQQNSSVDMLDAAIKLE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
118	Sulfoxidation	SSDSDSAMADMKILR CCCCHHHHHHHHHHH	3.63	23289948
121	Sulfoxidation	SDSAMADMKILRTLA CHHHHHHHHHHHHHH	1.79	23289948
345	Phosphorylation	ASTRAIDSLINYETV HHHHHHHHHHCHHHH	25.65	23776212
349	Phosphorylation	AIDSLINYETVKYFN HHHHHHCHHHHHCCC	13.14	23776212
351	Phosphorylation	DSLINYETVKYFNNE HHHHCHHHHHCCCCC	16.37	23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AB25B_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AB25B_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AB25B_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CNG13_ARATH	CNGC13	physical	22737156
UBQ3_ARATH	UBQ3	physical	25907570

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.