dbPTM

AB19B_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	AB19B_ARATH
UniProt AC	Q9LJX0
Protein Name	ABC transporter B family member 19
Gene Name	ABCB19
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	1252
Subcellular Localization	Cell membrane Multi-pass membrane protein .
Protein Description	Auxin efflux transporter that acts as a negative regulator of light signaling to promote hypocotyl elongation. Mediates the accumulation of chlorophyll and anthocyanin, as well as the expression of genes in response to light. Participates in auxin efflux and thus regulates the polar auxin basipetal transport (from auxin-producing leaves to auxin-sensitive tissues, and from root tips to root elongating zone). Involved in diverse auxin-mediated responses including gravitropism, phototropism and lateral root formation..
Protein Sequence	MSETNTTDAKTVPAEAEKKKEQSLPFFKLFSFADKFDYLLMFVGSLGAIVHGSSMPVFFLLFGQMVNGFGKNQMDLHQMVHEVSRYSLYFVYLGLVVCFSSYAEIACWMYSGERQVAALRKKYLEAVLKQDVGFFDTDARTGDIVFSVSTDTLLVQDAISEKVGNFIHYLSTFLAGLVVGFVSAWKLALLSVAVIPGIAFAGGLYAYTLTGITSKSRESYANAGVIAEQAIAQVRTVYSYVGESKALNAYSDAIQYTLKLGYKAGMAKGLGLGCTYGIACMSWALVFWYAGVFIRNGQTDGGKAFTAIFSAIVGGMSLGQSFSNLGAFSKGKAAGYKLMEIINQRPTIIQDPLDGKCLDQVHGNIEFKDVTFSYPSRPDVMIFRNFNIFFPSGKTVAVVGGSGSGKSTVVSLIERFYDPNSGQILLDGVEIKTLQLKFLREQIGLVNQEPALFATTILENILYGKPDATMVEVEAAASAANAHSFITLLPKGYDTQVGERGVQLSGGQKQRIAIARAMLKDPKILLLDEATSALDASSESIVQEALDRVMVGRTTVVVAHRLCTIRNVDSIAVIQQGQVVETGTHEELIAKSGAYASLIRFQEMVGTRDFSNPSTRRTRSTRLSHSLSTKSLSLRSGSLRNLSYSYSTGADGRIEMISNAETDRKTRAPENYFYRLLKLNSPEWPYSIMGAVGSILSGFIGPTFAIVMSNMIEVFYYTDYDSMERKTKEYVFIYIGAGLYAVGAYLIQHYFFSIMGENLTTRVRRMMLSAILRNEVGWFDEDEHNSSLIAARLATDAADVKSAIAERISVILQNMTSLLTSFIVAFIVEWRVSLLILGTFPLLVLANFAQQLSLKGFAGDTAKAHAKTSMIAGEGVSNIRTVAAFNAQSKILSLFCHELRVPQKRSLYRSQTSGFLFGLSQLALYGSEALILWYGAHLVSKGVSTFSKVIKVFVVLVITANSVAETVSLAPEIIRGGEAVGSVFSVLDRQTRIDPDDADADPVETIRGDIEFRHVDFAYPSRPDVMVFRDFNLRIRAGHSQALVGASGSGKSSVIAMIERFYDPLAGKVMIDGKDIRRLNLKSLRLKIGLVQQEPALFAATIFDNIAYGKDGATESEVIDAARAANAHGFISGLPEGYKTPVGERGVQLSGGQKQRIAIARAVLKNPTVLLLDEATSALDAESECVLQEALERLMRGRTTVVVAHRLSTIRGVDCIGVIQDGRIVEQGSHSELVSRPEGAYSRLLQLQTHRI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	N-linked_Glycosylation	---MSETNTTDAKTV ---CCCCCCCCCCCC	36.61	-
408	Phosphorylation	GSGSGKSTVVSLIER CCCCCHHHHHHHHHH	28.54	23328941
592	Phosphorylation	HEELIAKSGAYASLI HHHHHHHCCCHHHHH	21.45	29654922
597	Phosphorylation	AKSGAYASLIRFQEM HHCCCHHHHHHHHHH	16.20	29654922
611	Phosphorylation	MVGTRDFSNPSTRRT HHCCCCCCCCCCCCC	52.71	29654922
614	Phosphorylation	TRDFSNPSTRRTRST CCCCCCCCCCCCHHH	38.50	27531888
615	Phosphorylation	RDFSNPSTRRTRSTR CCCCCCCCCCCHHHH	25.98	25561503
620	Phosphorylation	PSTRRTRSTRLSHSL CCCCCCHHHHHHHHC	19.78	25561503
621	Phosphorylation	STRRTRSTRLSHSLS CCCCCHHHHHHHHCC	32.13	25561503
624	Phosphorylation	RTRSTRLSHSLSTKS CCHHHHHHHHCCCCE	14.03	24894044
626	Phosphorylation	RSTRLSHSLSTKSLS HHHHHHHHCCCCEEE	22.19	30407730
628	Phosphorylation	TRLSHSLSTKSLSLR HHHHHHCCCCEEECC	36.48	19376835
629	Phosphorylation	RLSHSLSTKSLSLRS HHHHHCCCCEEECCC	29.91	30407730
631	Phosphorylation	SHSLSTKSLSLRSGS HHHCCCCEEECCCCC	24.23	25561503
633	Phosphorylation	SLSTKSLSLRSGSLR HCCCCEEECCCCCCC	28.91	25561503
641	N-linked_Glycosylation	LRSGSLRNLSYSYST CCCCCCCCEEEEEEC	38.34	-
643	Phosphorylation	SGSLRNLSYSYSTGA CCCCCCEEEEEECCC	18.64	23776212
644	Phosphorylation	GSLRNLSYSYSTGAD CCCCCEEEEEECCCC	18.13	23776212
645	Phosphorylation	SLRNLSYSYSTGADG CCCCEEEEEECCCCC	14.83	23776212
646	Phosphorylation	LRNLSYSYSTGADGR CCCEEEEEECCCCCC	11.30	23776212
647	Phosphorylation	RNLSYSYSTGADGRI CCEEEEEECCCCCCE	17.90	30291188
648	Phosphorylation	NLSYSYSTGADGRIE CEEEEEECCCCCCEE	28.31	23776212
758	N-linked_Glycosylation	FFSIMGENLTTRVRR HHHHHCCCHHHHHHH	36.64	-
785	N-linked_Glycosylation	WFDEDEHNSSLIAAR CCCCCCCCHHHHHHH	31.11	-
814	N-linked_Glycosylation	RISVILQNMTSLLTS HHHHHHHHHHHHHHH	32.05	-
881	Phosphorylation	EGVSNIRTVAAFNAQ CCCCCHHHHHHHHHH	15.65	29797451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of AB19B_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of AB19B_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of AB19B_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
PINI_ARATH	PIN1	genetic	17237354
PINI_ARATH	PIN1	physical	17237354

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of AB19B_ARATH

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks."; Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.; Plant Physiol. 150:889-903(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-628 AND SER-647, ANDMASS SPECTROMETRY.	19376835 [Abstract]