dbPTM

AB17A_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	AB17A_RAT
UniProt AC	Q5XIJ5
Protein Name	Alpha/beta hydrolase domain-containing protein 17A {ECO:0000305}
Gene Name	Abhd17a {ECO:0000312\|RGD:1359682}
Organism	Rattus norvegicus (Rat).
Sequence Length	310
Subcellular Localization	Cell membrane Lipid-anchor Cytoplasmic side . Recycling endosome membrane Lipid-anchor Cytoplasmic side . Cell projection, dendritic spine . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density .
Protein Description	Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. [PubMed: 27307232 Has depalmitoylating activity towards NRAS (By similarity Has depalmitoylating activity towards DLG4/PSD95]
Protein Sequence	MNGLSVSELCCLFCCPPCPGRIAAKLAFLPPEPTYSLVPEPEPGPGGAGAAPSGPLRTSAATPGRWKIHLTERADFQYGQRELDTIEVFVTKSARANRIACMYVRCVPGARYTVLFSHGNAVDLGQMCSFYVGLGTRIGCNIFSYDYSGYGISSGRPSEKNLYADIDAAWQALRTRYGISPDSIILYGQSIGTVPTVDLASRYECAAVVLHSPLTSGMRVAFPDTKKTYCFDAFPNIEKVSKITSPVLIIHGTEDEVIDFSHGLALYERCPKAVEPLWVEGAGHNDIELYSQYLERLRRFISQELPSQRT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
62	Phosphorylation	PLRTSAATPGRWKIH CCCCCCCCCCEEEEE	25403869
92	Ubiquitination	TIEVFVTKSARANRI EEEEEEECHHHHCCE	-
226	Ubiquitination	RVAFPDTKKTYCFDA EEECCCCCCEEEECC	-
302	Phosphorylation	ERLRRFISQELPSQR HHHHHHHHHHCCCCC	-
307	Phosphorylation	FISQELPSQRT---- HHHHHCCCCCC----	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of AB17A_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of AB17A_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of AB17A_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of AB17A_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of AB17A_RAT

Related Literatures of Post-Translational Modification