AATC_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AATC_RAT
• UniProt AC: P13221
• Protein Name: Aspartate aminotransferase, cytoplasmic
• Gene Name: Got1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 413
• Subcellular Localization: Cytoplasm.
• Protein Description: Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain..
• Protein Sequence: MAPPSFFAQVPQAPPVLVFKLIADFRDDPDPRKVNLGVGAYRTDDSQPWVLPVVRKVEQKIANDHSLNHEYLPILGLAEFRSCASQLVLGDNSPALRENRVGGVQSLGGTGALRIGADFLGRWYNGTDNKNTPVYVSSPTWENHNGVFSAAGFKDIRSYRYWDAEKRGLDLQGFLNDLENAPEFSIFVLHACAHNPTGTDPTEEEWKQIAAVMKRRFLFPFFDSAYQGFASGDLEKDAWAIRYFVSEGFELFCAQSFSKNFGLYNERVGNLTVVGKEHDSVLRVLSQMEKIVRITWSNPPAQGARIVATTLSNPELFKEWKGNVKTMADRILTMRSELRARLEALKTPGTWSHITEQIGMFSFTGLNPKQVEYLVNEKHIYLMPSGRINMCGLTTKNLDYVATSINEAVTKFQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Phosphorylation	LGVGAYRTDDSQPWV EECCCEECCCCCCCC	31.33	24945867
46	Phosphorylation	GAYRTDDSQPWVLPV CCEECCCCCCCCHHH	40.74	24945867
56	Acetylation	WVLPVVRKVEQKIAN CCHHHHHHHHHHHHC	38.21	22902405
60	Acetylation	VVRKVEQKIANDHSL HHHHHHHHHHCCCCC	30.22	22902405
66	Phosphorylation	QKIANDHSLNHEYLP HHHHCCCCCCCCCHH	33.46	23984901
71	Phosphorylation	DHSLNHEYLPILGLA CCCCCCCCHHHHHHH	15.38	23984901
83	S-nitrosocysteine	GLAEFRSCASQLVLG HHHHHHHHHHHHHHC	3.53	-
83	S-nitrosylation	GLAEFRSCASQLVLG HHHHHHHHHHHHHHC	3.53	22178444
132	Phosphorylation	NGTDNKNTPVYVSSP CCCCCCCCCEEEECC	18.75	25575281
135	Phosphorylation	DNKNTPVYVSSPTWE CCCCCCEEEECCCCC	8.87	25575281
137	Phosphorylation	KNTPVYVSSPTWENH CCCCEEEECCCCCCC	16.95	23984901
138	Phosphorylation	NTPVYVSSPTWENHN CCCEEEECCCCCCCC	19.12	23984901
140	Phosphorylation	PVYVSSPTWENHNGV CEEEECCCCCCCCCC	47.56	23984901
149	Phosphorylation	ENHNGVFSAAGFKDI CCCCCCCCCCCCCCH	18.14	22673903
154	Acetylation	VFSAAGFKDIRSYRY CCCCCCCCCHHHHCC	51.86	22902405
166	Acetylation	YRYWDAEKRGLDLQG HCCEEHHHCCCCHHH	54.19	22902405
214	Acetylation	KQIAAVMKRRFLFPF HHHHHHHHHHCHHHH	33.55	22902405
259	N6-(pyridoxal phosphate)lysine	FCAQSFSKNFGLYNE EEEEHHHHHCCCCCC	55.04	-
259	Other	FCAQSFSKNFGLYNE EEEEHHHHHCCCCCC	55.04	-
276	Acetylation	GNLTVVGKEHDSVLR CCEEEECCCHHHHHH	40.02	22902405
290	Acetylation	RVLSQMEKIVRITWS HHHHHHHHHEEEEEC	40.95	22902405
290	Ubiquitination	RVLSQMEKIVRITWS HHHHHHHHHEEEEEC	40.95	-
295	Phosphorylation	MEKIVRITWSNPPAQ HHHHEEEEECCCCCC	16.57	26022182
310	Phosphorylation	GARIVATTLSNPELF CCEEEEEECCCHHHH	20.60	23984901
312	Phosphorylation	RIVATTLSNPELFKE EEEEEECCCHHHHHH	48.52	23984901
318	Acetylation	LSNPELFKEWKGNVK CCCHHHHHHHCCCHH	75.25	22902405
318	Ubiquitination	LSNPELFKEWKGNVK CCCHHHHHHHCCCHH	75.25	-
321	Acetylation	PELFKEWKGNVKTMA HHHHHHHCCCHHHHH	41.52	22902405
321	Ubiquitination	PELFKEWKGNVKTMA HHHHHHHCCCHHHHH	41.52	-
325	Acetylation	KEWKGNVKTMADRIL HHHCCCHHHHHHHHH	36.26	22902405
373	Phosphorylation	LNPKQVEYLVNEKHI CCHHHEEEEECCCEE	19.66	-
378	Acetylation	VEYLVNEKHIYLMPS EEEEECCCEEEECCC	30.05	22902405
411	Acetylation	SINEAVTKFQ----- HHHHHHHHCC-----	34.86	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AATC_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AATC_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AATC_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of AATC_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.