AAKG2_MOUSE - dbPTM
AAKG2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AAKG2_MOUSE
UniProt AC Q91WG5
Protein Name 5'-AMP-activated protein kinase subunit gamma-2
Gene Name Prkag2
Organism Mus musculus (Mouse).
Sequence Length 566
Subcellular Localization
Protein Description AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive (By similarity)..
Protein Sequence MGSAAMDTKKKKEVSSPGGSSGKKNPSLKRRSLRVHIPDLSSFAMPLLDGDVENSEKHSSRKVDSPFSSGSPSRGLFSRGPQPRPSSPVSAPVRPKTSPGSPKTVFPFSYQESPPRSPRRMSFSGIFRSSSKESSPNSNPSTSPGGIRFFSRSRKTSSVSSSPSTPTQVTKQHPFPLESYKQEPERPESRIYASSSPPDTGQRFCLAFQSPARPPLASPTYHAPLRTAVLAAAPGPAEAGMLEKLEFQEEEDSESGVYMRFMRSHKCYDIVPTSSKLVVFDTTLQVKKAFFALVANGVRAAPLWESKKQSFVGMLTITDFINILHRYYKSPMVQIYELEEHKIETWRELYLQETFKPLVNISPDASLFDAVYSLIKNKIHRLPVIDPISGNALYILTHKRILKFLQLFMSDMPKPAFMKQNLDELGIGTYHNIAFIHPDTPIIKALNIFVERRISALPVVDESGKVVDIYSKFDVINLAAEKTYNNLDITVTQALQHRSQYFEGVVKCSKLETLETIVDRIVRAEVHRLVVVNEADSIVGIISLSDILQALILTPAGAKQKETETE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
15PhosphorylationTKKKKEVSSPGGSSG
CCCCCCCCCCCCCCC		31.7229899451
16PhosphorylationKKKKEVSSPGGSSGK
CCCCCCCCCCCCCCC		32.5127841257
21PhosphorylationVSSPGGSSGKKNPSL
CCCCCCCCCCCCHHH		58.8829899451
32PhosphorylationNPSLKRRSLRVHIPD
CHHHHCCEEEEECCC		25.2620811261
41PhosphorylationRVHIPDLSSFAMPLL
EEECCCHHHHCHHCC		30.6923984901
42PhosphorylationVHIPDLSSFAMPLLD
EECCCHHHHCHHCCC		25.0723984901
65PhosphorylationHSSRKVDSPFSSGSP
HCCCCCCCCCCCCCC		30.7225521595
68PhosphorylationRKVDSPFSSGSPSRG
CCCCCCCCCCCCCCC		36.8523684622
69PhosphorylationKVDSPFSSGSPSRGL
CCCCCCCCCCCCCCC		43.6023684622
71PhosphorylationDSPFSSGSPSRGLFS
CCCCCCCCCCCCCCC		22.9625521595
73PhosphorylationPFSSGSPSRGLFSRG
CCCCCCCCCCCCCCC		40.4521082442
78PhosphorylationSPSRGLFSRGPQPRP
CCCCCCCCCCCCCCC		41.1722817900
86PhosphorylationRGPQPRPSSPVSAPV
CCCCCCCCCCCCCCC		48.8623684622
87PhosphorylationGPQPRPSSPVSAPVR
CCCCCCCCCCCCCCC		31.8125521595
90PhosphorylationPRPSSPVSAPVRPKT
CCCCCCCCCCCCCCC		30.1825521595
97PhosphorylationSAPVRPKTSPGSPKT
CCCCCCCCCCCCCCE		42.7221183079
101PhosphorylationRPKTSPGSPKTVFPF
CCCCCCCCCCEECCC		26.977602467
104PhosphorylationTSPGSPKTVFPFSYQ
CCCCCCCEECCCCCC		30.6623984901
109PhosphorylationPKTVFPFSYQESPPR
CCEECCCCCCCCCCC		26.5881018321
110PhosphorylationKTVFPFSYQESPPRS
CEECCCCCCCCCCCC		19.3726643407
113PhosphorylationFPFSYQESPPRSPRR
CCCCCCCCCCCCCCC		25.3625521595
117PhosphorylationYQESPPRSPRRMSFS
CCCCCCCCCCCCCEE		28.6525521595
122PhosphorylationPRSPRRMSFSGIFRS
CCCCCCCCEEEECCC		17.9123684622
124PhosphorylationSPRRMSFSGIFRSSS
CCCCCCEEEECCCCC		24.5421743459
129PhosphorylationSFSGIFRSSSKESSP
CEEEECCCCCCCCCC		28.3724759943
130PhosphorylationFSGIFRSSSKESSPN
EEEECCCCCCCCCCC		40.9722817900
131PhosphorylationSGIFRSSSKESSPNS
EEECCCCCCCCCCCC		41.5129899451
134PhosphorylationFRSSSKESSPNSNPS
CCCCCCCCCCCCCCC		55.6323684622
135PhosphorylationRSSSKESSPNSNPST
CCCCCCCCCCCCCCC		29.2325521595
138PhosphorylationSKESSPNSNPSTSPG
CCCCCCCCCCCCCCC		54.2023684622
141PhosphorylationSSPNSNPSTSPGGIR
CCCCCCCCCCCCCEE		45.8522324799
142PhosphorylationSPNSNPSTSPGGIRF
CCCCCCCCCCCCEEE		39.9523684622
143PhosphorylationPNSNPSTSPGGIRFF
CCCCCCCCCCCEEEE		26.3625521595
151PhosphorylationPGGIRFFSRSRKTSS
CCCEEEEECCCCCCC		27.0023984901
156PhosphorylationFFSRSRKTSSVSSSP
EEECCCCCCCCCCCC		25.7329472430
157PhosphorylationFSRSRKTSSVSSSPS
EECCCCCCCCCCCCC		31.6025521595
158PhosphorylationSRSRKTSSVSSSPST
ECCCCCCCCCCCCCC		31.1129899451
160PhosphorylationSRKTSSVSSSPSTPT
CCCCCCCCCCCCCCC		27.3529899451
161PhosphorylationRKTSSVSSSPSTPTQ
CCCCCCCCCCCCCCC		44.0825521595
162PhosphorylationKTSSVSSSPSTPTQV
CCCCCCCCCCCCCCC		18.5025521595
164PhosphorylationSSVSSSPSTPTQVTK
CCCCCCCCCCCCCCC		49.3025521595
165PhosphorylationSVSSSPSTPTQVTKQ
CCCCCCCCCCCCCCC		33.4725521595
167PhosphorylationSSSPSTPTQVTKQHP
CCCCCCCCCCCCCCC		35.4419060867
170PhosphorylationPSTPTQVTKQHPFPL
CCCCCCCCCCCCCCH		18.3729472430
180PhosphorylationHPFPLESYKQEPERP
CCCCHHHHCCCCCCC		13.8122871156
192PhosphorylationERPESRIYASSSPPD
CCCCCCEEECCCCCC		10.1830635358
194PhosphorylationPESRIYASSSPPDTG
CCCCEEECCCCCCCC		17.8730635358
195PhosphorylationESRIYASSSPPDTGQ
CCCEEECCCCCCCCC		38.4025521595
196PhosphorylationSRIYASSSPPDTGQR
CCEEECCCCCCCCCC		37.6525521595
200PhosphorylationASSSPPDTGQRFCLA
ECCCCCCCCCCEEEE		40.7727742792
210PhosphorylationRFCLAFQSPARPPLA
CEEEEECCCCCCCCC		17.6724759943
218PhosphorylationPARPPLASPTYHAPL
CCCCCCCCCCCCCCH		26.009536077
220PhosphorylationRPPLASPTYHAPLRT
CCCCCCCCCCCCHHH		25.9923984901
221PhosphorylationPPLASPTYHAPLRTA
CCCCCCCCCCCHHHH		10.2023984901
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AAKG2_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AAKG2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AAKG2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of AAKG2_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AAKG2_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65; SER-71; SER-73;SER-90; SER-138; SER-158; SER-161 AND SER-162, AND MASS SPECTROMETRY.
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-196, AND MASSSPECTROMETRY.

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