dbPTM

AA2BR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	AA2BR_HUMAN
UniProt AC	P29275
Protein Name	Adenosine receptor A2b
Gene Name	ADORA2B
Organism	Homo sapiens (Human).
Sequence Length	332
Subcellular Localization	Cell membrane Multi-pass membrane protein.
Protein Description	Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase..
Protein Sequence	MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
153	N-linked_Glycosylation	SKDSATNNCTEPWDG CCCCCCCCCCCCCCC	29.72	UniProtKB CARBOHYD
163	N-linked_Glycosylation	EPWDGTTNESCCLVK CCCCCCCCHHHHHHH	38.74	UniProtKB CARBOHYD
204	Ubiquitination	IMLVIYIKIFLVACR HHHHHHHHHHHHHHH	15.50	-
299	Phosphorylation	YRNRDFRYTFHKIIS HCCCCHHHHHHHHHH	17.47	29759185
300	Phosphorylation	RNRDFRYTFHKIISR CCCCHHHHHHHHHHH	18.27	29759185
311	S-palmitoylation	IISRYLLCQADVKSG HHHHHHHHHCCCCCC	2.64	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of AA2BR_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of AA2BR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of AA2BR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
TPD54_HUMAN	TPD52L2	physical	21988832
ZN267_HUMAN	ZNF267	physical	21988832

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of AA2BR_HUMAN

Related Literatures of Post-Translational Modification