A20A1_HUMAN - dbPTM
A20A1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID A20A1_HUMAN
UniProt AC Q5TYW2
Protein Name Ankyrin repeat domain-containing protein 20A1
Gene Name ANKRD20A1
Organism Homo sapiens (Human).
Sequence Length 823
Subcellular Localization
Protein Description
Protein Sequence MKLFGFGSRRGQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDLDALDKQHRTALHLACTSGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEKMVEFLLKKKASSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAISHHLTKIQQQILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQCVPEKVSEPLPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAEQALPVASEEEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLEPTVQSLEMKSKTARNTPNWDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKAENEFLTEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLVLEEKSKKLMNECDHLKESLFQYEREKTEGVVSIKEDKYFQTSRKTI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
57PhosphorylationERCLARRSGDLDALD
HHHHHHHCCCHHHHC		30.9822210691
65UbiquitinationGDLDALDKQHRTALH
CCHHHHCHHHHHHHH		49.18-
84PhosphorylationSGHVQVVTLLVNRKC
CCCEEEEEEEECCCC		18.6022210691
246UbiquitinationAISHHLTKIQQQILE
HHHHHHHHHHHHHHH		44.89-
264PhosphorylationKILKKEKSDVGSSDE
HHHHHHHCCCCCCCH		38.3228111955
268PhosphorylationKEKSDVGSSDESAVS
HHHCCCCCCCHHHHH		34.1728111955
269PhosphorylationEKSDVGSSDESAVSI
HHCCCCCCCHHHHHH		39.2028111955
272PhosphorylationDVGSSDESAVSIFHE
CCCCCCHHHHHHHHH		38.6728111955
284PhosphorylationFHELRVDSLPASDDK
HHHHHCCCCCCCCCC		33.1428102081
288PhosphorylationRVDSLPASDDKDLNV
HCCCCCCCCCCCCCH		44.3928102081
297PhosphorylationDKDLNVATKQCVPEK
CCCCCHHHCCCCCCC		19.8445741399
357PhosphorylationVQRKNVQTLRAEQAL
HHHCCHHHHHHHHHC		17.5826074081
368PhosphorylationEQALPVASEEEQERH
HHHCCCCCHHHHHHH		45.8626074081
391PhosphorylationQVKEGNNTNKSEKIQ
CCCCCCCCCHHHHCE		48.2830242111
394PhosphorylationEGNNTNKSEKIQLSE
CCCCCCHHHHCEECC		46.3130242111
409PhosphorylationNICDSTSSAAAGRLT
CCHHCCCHHHHHHHH		23.24-
482PhosphorylationEAKQLEPTVQSLEMK
HHHHCCHHHHHHHHH		23.0826503514
492PhosphorylationSLEMKSKTARNTPNW
HHHHHHCCCCCCCCC		37.6326503514
547AcetylationNKYLKDIKIVKETNA
HHHHHHHHHHHHHHH		52.137683757
558UbiquitinationETNAALEKYIKLNEE
HHHHHHHHHHHHCHH		53.80-
582UbiquitinationQQELNDLKAENTRLN
HHHHHHHHHHHHHHH		57.42-
598PhosphorylationELLKEKESKKRLEAD
HHHHHHHHHHHHHHH		55.3229457462
618PhosphorylationSRLAAAISKHSESVK
HHHHHHHHHCCHHHH		21.4224732914
619UbiquitinationRLAAAISKHSESVKT
HHHHHHHHCCHHHHC		45.07-
621PhosphorylationAAAISKHSESVKTER
HHHHHHCCHHHHCHH		34.9924719451
641PhosphorylationLERTRDVSVQVEMSS
HHHHCCCEEEEEECH		15.892495443
647PhosphorylationVSVQVEMSSAISKVK
CEEEEEECHHHHHHH		11.7818552033
651PhosphorylationVEMSSAISKVKAENE
EEECHHHHHHHHHCH		30.9818552039
681PhosphorylationLKDKFRKTRDSLRKK
HHHHHHHHHHHHHHH		35.1424702127
684PhosphorylationKFRKTRDSLRKKSLA
HHHHHHHHHHHHHHH		27.128656129
713PhosphorylationTQEMKEMYQNAEAKV
HHHHHHHHHHHHHHH		10.3328796482
762PhosphorylationEDHKEIVTNIQRGFI
CCHHHHHHHHHHHHH		32.0629632367
773AcetylationRGFIESGKKDLVLEE
HHHHHCCCCCHHHHH		53.0112835005
795PhosphorylationECDHLKESLFQYERE
HHHHHHHHHHHHHHH		32.6630266825
799PhosphorylationLKESLFQYEREKTEG
HHHHHHHHHHHHCCC		15.0430266825
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of A20A1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of A20A1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of A20A1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of A20A1_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of A20A1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-297, AND MASSSPECTROMETRY.

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