| UniProt ID | A1AT2_MOUSE | |
|---|---|---|
| UniProt AC | P22599 | |
| Protein Name | Alpha-1-antitrypsin 1-2 | |
| Gene Name | Serpina1b | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 413 | |
| Subcellular Localization | Secreted . | |
| Protein Description | Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin.. | |
| Protein Sequence | MTPSISWGLLLLAGLCCMVPSFLAEDVQETDTSQKDQSPASHEIATNLGDFAISLYRELVHQSNTSNIFFSPVSIATAFAMLSLGSKGDTHTQILEGLQFNLTQTSEADIHKSFQHLLQTLNRPDSELQLSTGNGLFVNNDLKLVEKFLEEAKNHYQAEVFSVNFAESEEAKKVINDFVEKGTQGKIVEAVKELDQDTVFALANYILFKGKWKKPFDPENTEEAEFHVDKSTTVKVPMMMLSGMLDVHHCSILSSWVLLMDYAGNASAVFLLPEDGKMQHLEQTLNKELISKILLNRRRRLVQIHIPRLSISGDYNLKTLMSPLGITRIFNNGADLSGITEENAPLKLSKAVHKAVLTIDETGTEAAAATVFEAVPMSMPPILRFDHPFLFIIFEEHTQSPIFVGKVVDPTHK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 38 | Phosphorylation | DTSQKDQSPASHEIA CCCCCCCCCHHHHHH | 32.35 | 23984901 | |
| 41 | Phosphorylation | QKDQSPASHEIATNL CCCCCCHHHHHHHHH | 25.66 | 27180971 | |
| 46 | Phosphorylation | PASHEIATNLGDFAI CHHHHHHHHHHHHHH | 36.32 | 23984901 | |
| 64 | N-linked_Glycosylation | RELVHQSNTSNIFFS HHHHHHCCCCCCCCC | 40.74 | - | |
| 101 | N-linked_Glycosylation | ILEGLQFNLTQTSEA HHHHCEECCCCCCHH | 29.26 | 16944957 | |
| 147 | Ubiquitination | NDLKLVEKFLEEAKN CCHHHHHHHHHHHHH | 48.01 | - | |
| 147 | Acetylation | NDLKLVEKFLEEAKN CCHHHHHHHHHHHHH | 48.01 | - | |
| 173 | Ubiquitination | AESEEAKKVINDFVE CCCHHHHHHHHHHHH | 56.23 | - | |
| 181 | Acetylation | VINDFVEKGTQGKIV HHHHHHHHCCCCCHH | 63.05 | - | |
| 181 | Ubiquitination | VINDFVEKGTQGKIV HHHHHHHHCCCCCHH | 63.05 | - | |
| 186 | Ubiquitination | VEKGTQGKIVEAVKE HHHCCCCCHHHHHHH | 33.49 | 27667366 | |
| 214 | Acetylation | LFKGKWKKPFDPENT HHCCCCCCCCCCCCC | 50.21 | 55170063 | |
| 265 | N-linked_Glycosylation | LLMDYAGNASAVFLL HHHHHCCCCEEEEEE | 23.66 | 16944957 | |
| 287 | Ubiquitination | HLEQTLNKELISKIL HHHHHHCHHHHHHHH | 57.94 | 22790023 | |
| 292 | Acetylation | LNKELISKILLNRRR HCHHHHHHHHHHCCH | 30.31 | 23864654 | |
| 292 | Ubiquitination | LNKELISKILLNRRR HCHHHHHHHHHHCCH | 30.31 | 22790023 | |
| 318 | Ubiquitination | ISGDYNLKTLMSPLG ECCCCCHHHHCCCCC | 35.65 | 22790023 | |
| 347 | Ubiquitination | TEENAPLKLSKAVHK CCCCCCHHHHHHHHH | 50.05 | 22790023 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of A1AT2_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of A1AT2_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of A1AT2_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of A1AT2_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| N-linked Glycosylation | |
| Reference | PubMed |
| "Proteome-wide characterization of N-glycosylation events by diagonalchromatography."; Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J.,Gevaert K.; J. Proteome Res. 5:2438-2447(2006). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-101 AND ASN-265, AND MASSSPECTROMETRY. | |
