5NT1B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 5NT1B_HUMAN
• UniProt AC: Q96P26
• Protein Name: Cytosolic 5'-nucleotidase 1B
• Gene Name: NT5C1B
• Organism: Homo sapiens (Human).
• Sequence Length: 610
• Subcellular Localization: Cytoplasm.
• Protein Description: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (By similarity)..
• Protein Sequence: MSQTSLKQKKNEPGMRSSKESLEAEKRKESDKTGVRLSNQMRRAVNPNHSLRCCPFQGHSSCRRCLCAAEGTALGPCHTIRIYIHMCLLWEQGQQITMMRGSQESSLRKTDSRGYLVRSQWSRISRSPSTKAPSIDEPRSRNTSAKLPSSSTSSRTPSTSPSLHDSSPPPLSGQPSLQPPASPQLPRSLDSRPPTPPEPDPGSRRSTKMQENPEAWAQGIVREIRQTRDSQPLEYSRTSPTEWKSSSQRRGIYPASTQLDRNSLSEQQQQQREDEDDYEAAYWASMRSFYEKNPSCSRPWPPKPKNAITIALSSCALFNMVDGRKIYEQEGLEKYMEYQLTNENVILTPGPAFRFVKALQYVNARLRDLYPDEQDLFDIVLMTNNHAQVGVRLINSVNHYGLLIDRFCLTGGKDPIGYLKAYLTNLYIAADSEKVQEAIQEGIASATMFDGAKDMAYCDTQLRVAFDGDAVLFSDESEHFTKEHGLDKFFQYDTLCESKPLAQGPLKGFLEDLGRLQKKFYAKNERLLCPIRTYLVTARSAASSGARVLKTLRRWGLEIDEALFLAGAPKSPILVKIRPHIFFDDHMFHIEGAQRLGSIAAYGFNKKFSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MSQTSLKQKKN ----CCHHHHHHHCC	28.81	17081983
17	Phosphorylation	KNEPGMRSSKESLEA CCCCCCCCCHHHHHH	36.55	30622161
18	Phosphorylation	NEPGMRSSKESLEAE CCCCCCCCHHHHHHH	30.03	30622161
21	Phosphorylation	GMRSSKESLEAEKRK CCCCCHHHHHHHHHH	34.93	30622161
33	Phosphorylation	KRKESDKTGVRLSNQ HHHHHHHHCHHHHHH	45.99	27251275
38	Phosphorylation	DKTGVRLSNQMRRAV HHHCHHHHHHHHHHC	17.91	27251275
42 (in isoform 2)	Phosphorylation	-	17.40	-
83	Phosphorylation	PCHTIRIYIHMCLLW CCHHHHHHHHHHHHH	3.79	-
102	Phosphorylation	QITMMRGSQESSLRK EEEEECCCCCHHHCC	22.02	29396449
105	Phosphorylation	MMRGSQESSLRKTDS EECCCCCHHHCCCCC	27.34	29396449
110	Phosphorylation	QESSLRKTDSRGYLV CCHHHCCCCCCCCCC	32.54	30622161
112	Phosphorylation	SSLRKTDSRGYLVRS HHHCCCCCCCCCCHH	32.60	30622161
115	Phosphorylation	RKTDSRGYLVRSQWS CCCCCCCCCCHHHHH	10.83	28122231
119	Phosphorylation	SRGYLVRSQWSRISR CCCCCCHHHHHCCCC	28.64	26074081
122	Phosphorylation	YLVRSQWSRISRSPS CCCHHHHHCCCCCCC	16.46	26074081
125	Phosphorylation	RSQWSRISRSPSTKA HHHHHCCCCCCCCCC	26.12	26074081
127	Phosphorylation	QWSRISRSPSTKAPS HHHCCCCCCCCCCCC	19.19	26074081
129	Phosphorylation	SRISRSPSTKAPSID HCCCCCCCCCCCCCC	43.73	26074081
130	Phosphorylation	RISRSPSTKAPSIDE CCCCCCCCCCCCCCC	34.31	26074081
134	Phosphorylation	SPSTKAPSIDEPRSR CCCCCCCCCCCCCCC	47.75	22167270
140	Phosphorylation	PSIDEPRSRNTSAKL CCCCCCCCCCCCCCC	40.37	26074081
143	Phosphorylation	DEPRSRNTSAKLPSS CCCCCCCCCCCCCCC	29.02	-
146	Methylation	RSRNTSAKLPSSSTS CCCCCCCCCCCCCCC	61.78	-
152	Phosphorylation	AKLPSSSTSSRTPST CCCCCCCCCCCCCCC	32.44	-
154	Phosphorylation	LPSSSTSSRTPSTSP CCCCCCCCCCCCCCC	40.02	-
156	Phosphorylation	SSSTSSRTPSTSPSL CCCCCCCCCCCCCCC	24.44	25693802
158	Phosphorylation	STSSRTPSTSPSLHD CCCCCCCCCCCCCCC	40.69	25693802
159	Phosphorylation	TSSRTPSTSPSLHDS CCCCCCCCCCCCCCC	45.95	25693802
160	Phosphorylation	SSRTPSTSPSLHDSS CCCCCCCCCCCCCCC	19.48	25693802
162	Phosphorylation	RTPSTSPSLHDSSPP CCCCCCCCCCCCCCC	37.80	25693802
166	Phosphorylation	TSPSLHDSSPPPLSG CCCCCCCCCCCCCCC	33.71	25693802
167	Phosphorylation	SPSLHDSSPPPLSGQ CCCCCCCCCCCCCCC	47.70	25693802
172	Phosphorylation	DSSPPPLSGQPSLQP CCCCCCCCCCCCCCC	40.95	25693802
176	Phosphorylation	PPLSGQPSLQPPASP CCCCCCCCCCCCCCC	31.58	25693802
182	Phosphorylation	PSLQPPASPQLPRSL CCCCCCCCCCCCCCC	20.96	25693802
188	Phosphorylation	ASPQLPRSLDSRPPT CCCCCCCCCCCCCCC	34.29	24719451
191	Phosphorylation	QLPRSLDSRPPTPPE CCCCCCCCCCCCCCC	52.56	30622161
195	Phosphorylation	SLDSRPPTPPEPDPG CCCCCCCCCCCCCCC	54.91	30622161
203	Phosphorylation	PPEPDPGSRRSTKMQ CCCCCCCCCCCCCHH	29.88	30622161
227	Phosphorylation	IVREIRQTRDSQPLE HHHHHHHHCCCCCCC	26.96	30622161
230	Phosphorylation	EIRQTRDSQPLEYSR HHHHHCCCCCCCCCC	30.33	30622161
235	Phosphorylation	RDSQPLEYSRTSPTE CCCCCCCCCCCCCCC	15.90	25693802
236	Phosphorylation	DSQPLEYSRTSPTEW CCCCCCCCCCCCCCC	21.51	25693802
238	Phosphorylation	QPLEYSRTSPTEWKS CCCCCCCCCCCCCCC	32.87	25693802
239	Phosphorylation	PLEYSRTSPTEWKSS CCCCCCCCCCCCCCH	28.81	25693802
241	Phosphorylation	EYSRTSPTEWKSSSQ CCCCCCCCCCCCHHH	55.00	25693802
245	Phosphorylation	TSPTEWKSSSQRRGI CCCCCCCCHHHCCCC	35.97	26074081
246	Phosphorylation	SPTEWKSSSQRRGIY CCCCCCCHHHCCCCC	27.11	26074081
247	Phosphorylation	PTEWKSSSQRRGIYP CCCCCCHHHCCCCCC	34.49	26074081
253	Phosphorylation	SSQRRGIYPASTQLD HHHCCCCCCCCHHHC	8.79	26074081
256	Phosphorylation	RRGIYPASTQLDRNS CCCCCCCCHHHCCCC	16.51	26074081
257	Phosphorylation	RGIYPASTQLDRNSL CCCCCCCHHHCCCCC	34.95	26074081
263	Phosphorylation	STQLDRNSLSEQQQQ CHHHCCCCCCHHHHH	33.88	26074081
265	Phosphorylation	QLDRNSLSEQQQQQR HHCCCCCCHHHHHHH	32.93	26074081
285	Phosphorylation	YEAAYWASMRSFYEK HHHHHHHHHHHHHHH	10.69	-
288	Phosphorylation	AYWASMRSFYEKNPS HHHHHHHHHHHHCCC	24.44	-
313	Phosphorylation	NAITIALSSCALFNM CHHHHHHHHHHHHHH	17.85	25693802
314	Phosphorylation	AITIALSSCALFNMV HHHHHHHHHHHHHHC	12.31	25693802
361	Phosphorylation	RFVKALQYVNARLRD HHHHHHHHHHHHHHH	9.12	22817900
445	Phosphorylation	AIQEGIASATMFDGA HHHHCCCHHCCCCCC	23.50	30622161
447	Phosphorylation	QEGIASATMFDGAKD HHCCCHHCCCCCCCC	18.84	30622161
492	Phosphorylation	GLDKFFQYDTLCESK CCHHHCCCCCCCCCC	13.02	30622161
494	Phosphorylation	DKFFQYDTLCESKPL HHHCCCCCCCCCCCC	28.51	30622161
498	Phosphorylation	QYDTLCESKPLAQGP CCCCCCCCCCCCCCC	38.28	24719451
510	Ubiquitination	QGPLKGFLEDLGRLQ CCCCCHHHHHHHHHH	7.35	29967540
521	Phosphorylation	GRLQKKFYAKNERLL HHHHHHHHHHCCCEE	26.08	24719451
527	Ubiquitination	FYAKNERLLCPIRTY HHHHCCCEECCHHHH	4.75	29967540
533	Phosphorylation	RLLCPIRTYLVTARS CEECCHHHHHHHHHH	23.17	24719451
534	Phosphorylation	LLCPIRTYLVTARSA EECCHHHHHHHHHHH	6.85	23532336
537	Phosphorylation	PIRTYLVTARSAASS CHHHHHHHHHHHHHH	17.48	23532336
538	Phosphorylation	IRTYLVTARSAASSG HHHHHHHHHHHHHHH	8.92	24719451
550	Phosphorylation	SSGARVLKTLRRWGL HHHHHHHHHHHHHCC	42.53	24719451
554	Phosphorylation	RVLKTLRRWGLEIDE HHHHHHHHHCCCHHH	34.62	24719451
598	Phosphorylation	EGAQRLGSIAAYGFN HHHHHHHHHHHCCCC	17.41	30622161
602	Phosphorylation	RLGSIAAYGFNKKFS HHHHHHHCCCCCCCC	17.15	30622161
621	Ubiquitination	------------------ ------------------		23000965

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of 5NT1B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of 5NT1B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 5NT1B_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of 5NT1B_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.