5HT2A_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 5HT2A_RAT
• UniProt AC: P14842
• Protein Name: 5-hydroxytryptamine receptor 2A
• Gene Name: Htr2a
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 471
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Cell projection, axon . Cytoplasmic vesicle . Membrane, caveola . Cell projection, dendrite. Localizes to the postsynaptic thickening of axo-dendritic synapses..
• Protein Description: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction..
• Protein Sequence: MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	N-linked_Glycosylation	MEILCEDNISLSSIP CCEECCCCCCHHHCC	11.94	-
38	N-linked_Glycosylation	DFNSRDANTSEASNW CCCCCCCCCCHHHCC	48.72	-
44	N-linked_Glycosylation	ANTSEASNWTIDAEN CCCCHHHCCEECCCC	47.13	-
51	N-linked_Glycosylation	NWTIDAENRTNLSCE CCEECCCCCCCCCCC	58.77	-
54	N-linked_Glycosylation	IDAENRTNLSCEGYL ECCCCCCCCCCCCCC	27.07	-
273	Phosphorylation	TLCVSDLSTRAKLAS CEEECCHHHHHHHHH	22.34	25403869
274	Phosphorylation	LCVSDLSTRAKLASF EEECCHHHHHHHHHC	41.78	25403869
277	Ubiquitination	SDLSTRAKLASFSFL CCHHHHHHHHHCCCC	41.10	-
280	Phosphorylation	STRAKLASFSFLPQS HHHHHHHHCCCCCCC	31.68	19103592
298	Phosphorylation	SEKLFQRSIHREPGS HHHHHHHHHHCCCCC	16.38	25403869
314	Phosphorylation	AGRRTMQSISNEQKA HCHHHHHHHCHHHHH	19.70	19103592

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
314	S	Phosphorylation	Kinase	RPS6KA3	P51812	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of 5HT2A_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 5HT2A_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of 5HT2A_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.