3HIDH_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 3HIDH_MOUSE
• UniProt AC: Q99L13
• Protein Name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
• Gene Name: Hibadh
• Organism: Mus musculus (Mouse).
• Sequence Length: 335
• Subcellular Localization: Mitochondrion.
• Protein Sequence: MAASLGFRGAASGLWYWSGRRRPVGSLAAVCSRSMASKTPVGFIGLGNMGNPMAKNLMKHGYPLILYDVFPDVCKEFKEAGEQVASSPAEVAEKADRIITMLPSSMNAVEVYSGANGILKKVKKGSLLIDSSTIDPSVSKELAKEVEKMGAVFMDAPVSGGVGAARSGNLTFMVGGVEDEFAAAQELLECMGSNVVYCGAVGTGQSAKICNNMLLAISMIGTAEAMNLGIRSGLDPKLLAKILNMSSGRCWSSDTYNPVPGVMHGVPSSNNYQGGFGTTLMAKDLGLAQDSATSTKTPILLGSLAHQIYRMMCSKGYSKKDFSSVFQYLREEEPF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	LGFRGAASGLWYWSG CCCCHHHCCCEEECC	33.61	20495213
55	Acetylation	NMGNPMAKNLMKHGY CCCCHHHHHHHHCCC	44.34	23864654
55	Succinylation	NMGNPMAKNLMKHGY CCCCHHHHHHHHCCC	44.34	24315375
55	Ubiquitination	NMGNPMAKNLMKHGY CCCCHHHHHHHHCCC	44.34	-
59	Succinylation	PMAKNLMKHGYPLIL HHHHHHHHCCCCEEE	36.72	-
59	Acetylation	PMAKNLMKHGYPLIL HHHHHHHHCCCCEEE	36.72	23576753
59	Succinylation	PMAKNLMKHGYPLIL HHHHHHHHCCCCEEE	36.72	23806337
62	Phosphorylation	KNLMKHGYPLILYDV HHHHHCCCCEEEEEC	8.45	25777480
67	Phosphorylation	HGYPLILYDVFPDVC CCCCEEEEECCHHHH	11.76	25777480
75	Acetylation	DVFPDVCKEFKEAGE ECCHHHHHHHHHHHH	67.06	23576753
75	Succinylation	DVFPDVCKEFKEAGE ECCHHHHHHHHHHHH	67.06	-
75	Succinylation	DVFPDVCKEFKEAGE ECCHHHHHHHHHHHH	67.06	23806337
78	Glutarylation	PDVCKEFKEAGEQVA HHHHHHHHHHHHHHH	47.98	24703693
78	Succinylation	PDVCKEFKEAGEQVA HHHHHHHHHHHHHHH	47.98	23806337
78	Succinylation	PDVCKEFKEAGEQVA HHHHHHHHHHHHHHH	47.98	-
78	Acetylation	PDVCKEFKEAGEQVA HHHHHHHHHHHHHHH	47.98	23576753
86	Phosphorylation	EAGEQVASSPAEVAE HHHHHHHCCHHHHHH	37.69	23140645
87	Phosphorylation	AGEQVASSPAEVAEK HHHHHHCCHHHHHHH	20.56	23140645
94	Acetylation	SPAEVAEKADRIITM CHHHHHHHHHHHHHH	45.94	23864654
94	Succinylation	SPAEVAEKADRIITM CHHHHHHHHHHHHHH	45.94	23806337
94	Glutarylation	SPAEVAEKADRIITM CHHHHHHHHHHHHHH	45.94	24703693
94	Succinylation	SPAEVAEKADRIITM CHHHHHHHHHHHHHH	45.94	-
120	Acetylation	SGANGILKKVKKGSL HCCCCHHHHHHCCCE	54.31	23576753
120	Succinylation	SGANGILKKVKKGSL HCCCCHHHHHHCCCE	54.31	26388266
121	Acetylation	GANGILKKVKKGSLL CCCCHHHHHHCCCEE	56.70	2391515
124	Glutarylation	GILKKVKKGSLLIDS CHHHHHHCCCEEEEC	57.63	24703693
140	Succinylation	TIDPSVSKELAKEVE CCCHHHHHHHHHHHH	55.37	23806337
140	Succinylation	TIDPSVSKELAKEVE CCCHHHHHHHHHHHH	55.37	-
140	Acetylation	TIDPSVSKELAKEVE CCCHHHHHHHHHHHH	55.37	23864654
144	Succinylation	SVSKELAKEVEKMGA HHHHHHHHHHHHCCC	74.95	24315375
144	Acetylation	SVSKELAKEVEKMGA HHHHHHHHHHHHCCC	74.95	23576753
148	Succinylation	ELAKEVEKMGAVFMD HHHHHHHHCCCEEEE	48.05	23806337
148	Succinylation	ELAKEVEKMGAVFMD HHHHHHHHCCCEEEE	48.05	-
148	Acetylation	ELAKEVEKMGAVFMD HHHHHHHHCCCEEEE	48.05	23576753
159	Phosphorylation	VFMDAPVSGGVGAAR EEEECCCCCCCCCCC	28.86	29472430
210	S-nitrosocysteine	TGQSAKICNNMLLAI CCHHHHHHHHHHHHH	2.72	-
210	S-nitrosylation	TGQSAKICNNMLLAI CCHHHHHHHHHHHHH	2.72	21278135
237	Glutarylation	IRSGLDPKLLAKILN HCCCCCHHHHHHHHC	56.66	24703693
237	Succinylation	IRSGLDPKLLAKILN HCCCCCHHHHHHHHC	56.66	23806337
237	Succinylation	IRSGLDPKLLAKILN HCCCCCHHHHHHHHC	56.66	-
237	Acetylation	IRSGLDPKLLAKILN HCCCCCHHHHHHHHC	56.66	23576753
241	Succinylation	LDPKLLAKILNMSSG CCHHHHHHHHCCCCC	47.93	23806337
241	Ubiquitination	LDPKLLAKILNMSSG CCHHHHHHHHCCCCC	47.93	-
241	Glutarylation	LDPKLLAKILNMSSG CCHHHHHHHHCCCCC	47.93	24703693
241	Succinylation	LDPKLLAKILNMSSG CCHHHHHHHHCCCCC	47.93	-
241	Acetylation	LDPKLLAKILNMSSG CCHHHHHHHHCCCCC	47.93	23576753
250	S-nitrosylation	LNMSSGRCWSSDTYN HCCCCCCCCCCCCCC	4.76	21278135
250	S-nitrosocysteine	LNMSSGRCWSSDTYN HCCCCCCCCCCCCCC	4.76	-
296	Succinylation	QDSATSTKTPILLGS CCCCCCCCCCHHHHH	52.66	23806337
296	Succinylation	QDSATSTKTPILLGS CCCCCCCCCCHHHHH	52.66	-
296	Acetylation	QDSATSTKTPILLGS CCCCCCCCCCHHHHH	52.66	23864654
303	Phosphorylation	KTPILLGSLAHQIYR CCCHHHHHHHHHHHH	23.50	20495213
320	Succinylation	CSKGYSKKDFSSVFQ HCCCCCHHHHHHHHH	59.05	23806337
320	Ubiquitination	CSKGYSKKDFSSVFQ HCCCCCHHHHHHHHH	59.05	-
320	Succinylation	CSKGYSKKDFSSVFQ HCCCCCHHHHHHHHH	59.05	-
320	Acetylation	CSKGYSKKDFSSVFQ HCCCCCHHHHHHHHH	59.05	23576753

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of 3HIDH_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of 3HIDH_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 3HIDH_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of 3HIDH_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.