2ABB_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 2ABB_MOUSE
• UniProt AC: Q6ZWR4
• Protein Name: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
• Gene Name: Ppp2r2b
• Organism: Mus musculus (Mouse).
• Sequence Length: 443
• Subcellular Localization: Isoform 1: Cytoplasm. Cytoplasm, cytoskeleton. Membrane.; Isoform 2: Cytoplasm. Mitochondrion. Mitochondrion outer membrane. Under basal conditions, localizes to both cytosolic and mitochondrial compartments. Relocalizes from the cytosolic to the mit
• Protein Description: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity. Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance..
• Protein Sequence: MEEDIDTRKINNSFLRDHSYATEADIISTVEFNHTGELLATGDKGGRVVIFQREQESKNQVHRRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQNAAYFLLSTNDKTVKLWKVSERDKRPEGYNLKDEEGRLRDPATITTLRVPVLRPMDLMVEATPRRVFANAHTYHINSISVNSDYETYMSADDLRINLWNFEITNQSFNIVDIKPANMEELTEVITAAEFHPHHCNTFVYSSSKGTIRLCDMRASALCDRHTKFFEEPEDPSNRSFFSEIISSISDVKFSHSGRYIMTRDYLTVKVWDLNMENRPIETYQVHDYLRSKLCSLYENDCIFDKFECVWNGSDSVIMTGSYNNFFRMFDRNTKRDVTLEASRENSKPRAILKPRKVCVGGKRRKDEISVDSLDFSKKILHTAWHPSENIIAVAATNNLYIFQDKVN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
125	Ubiquitination	WKVSERDKRPEGYNL EEECCCCCCCCCCCC	75.87	-
275	Phosphorylation	PEDPSNRSFFSEIIS CCCCCCCHHHHHHHH	34.59	-
295	Phosphorylation	KFSHSGRYIMTRDYL EECCCCCEEEEECEE	9.89	28576409
298	Phosphorylation	HSGRYIMTRDYLTVK CCCCEEEEECEEEEE	15.72	28576409
301	Phosphorylation	RYIMTRDYLTVKVWD CEEEEECEEEEEEEE	10.86	28576409
303	Phosphorylation	IMTRDYLTVKVWDLN EEEECEEEEEEEEEC	16.44	28576409
331	Phosphorylation	YLRSKLCSLYENDCI HHHHHHHHHHCCCCC	44.41	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of 2ABB_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of 2ABB_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 2ABB_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARRB2_MOUSE	Arrb2	physical	16051150

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.