1A16_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 1A16_ARATH
• UniProt AC: Q9SAR0
• Protein Name: 1-aminocyclopropane-1-carboxylate synthase 6
• Gene Name: ACS6
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 495
• Protein Description: 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes catalyze the conversion of S-adenosyl-L-methionine (SAM) into 1-aminocyclopropane-1-carboxylate (ACC), a direct precursor of ethylene. Involved in bacterial flagellin-induced ethylene production..
• Protein Sequence: MVAFATEKKQDLNLLSKIASGDGHGENSSYFDGWKAYEENPFHPIDRPDGVIQMGLAENQLCGDLMRKWVLKHPEASICTSEGVNQFSDIAIFQDYHGLPEFRQAVAKFMEKTRNNKVKFDPDRIVMSGGATGAHETVAFCLANPGDGFLVPTPYYPGFDRDLRWRTGVNLVPVTCHSSNGFKITVEALEAAYENARKSNIPVKGLLVTNPSNPLGTTLDRECLKSLVNFTNDKGIHLIADEIYAATTFGQSEFISVAEVIEEIEDCNRDLIHIVYSLSKDMGLPGLRVGIVYSYNDRVVQIARKMSSFGLVSSQTQHLIAKMLSDEEFVDEFIRESKLRLAARHAEITTGLDGLGIGWLKAKAGLFLWMDLRNLLKTATFDSETELWRVIVHQVKLNVSPGGSFHCHEPGWFRVCFANMDHKTMETALERIRVFTSQLEEETKPMAATTMMAKKKKKCWQSNLRLSFSDTRRFDDGFFSPHSPVPPSPLVRAQT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
280	N6-(pyridoxal phosphate)lysine	HIVYSLSKDMGLPGL HHHHHHHHHCCCCCE	57.96	-
280	Other	HIVYSLSKDMGLPGL HHHHHHHHHCCCCCE	57.96	-
480	Phosphorylation	RFDDGFFSPHSPVPP CCCCCCCCCCCCCCC	21.31	15539472
483	Phosphorylation	DGFFSPHSPVPPSPL CCCCCCCCCCCCCHH	30.86	15539472
488	Phosphorylation	PHSPVPPSPLVRAQT CCCCCCCCHHCCCCC	25.46	15539472

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of 1A16_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of 1A16_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 1A16_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
P2C56_ARATH	ABI1	physical	24637173

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphorylation of 1-aminocyclopropane-1-carboxylic acid synthase byMPK6, a stress-responsive mitogen-activated protein kinase, inducesethylene biosynthesis in Arabidopsis.";
Liu Y., Zhang S.;
Plant Cell 16:3386-3399(2004).
Cited for: FUNCTION, PHOSPHORYLATION AT SER-480; SER-483 AND SER-488, ANDMUTAGENESIS OF SER-480; SER-483 AND SER-488.
PubMed: 15539472