dbPTM

1A12_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	1A12_ARATH
UniProt AC	Q06402
Protein Name	1-aminocyclopropane-1-carboxylate synthase 2
Gene Name	ACS2
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	496
Subcellular Localization
Protein Description	1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes catalyze the conversion of S-adenosyl-L-methionine (SAM) into 1-aminocyclopropane-1-carboxylate (ACC), a direct precursor of ethylene..
Protein Sequence	MGLPGKNKGAVLSKIATNNQHGENSEYFDGWKAYDKDPFHLSRNPHGIIQMGLAENQLCLDLIKDWVKENPEASICTLEGIHQFSDIANFQDYHGLKKFRQAIAHFMGKARGGRVTFDPERVVMSGGATGANETIMFCLADPGDVFLIPSPYYAAFDRDLRWRTGVEIIPVPCSSSDNFKLTVDAAEWAYKKAQESNKKVKGLILTNPSNPLGTMLDKDTLTNLVRFVTRKNIHLVVDEIYAATVFAGGDFVSVAEVVNDVDISEVNVDLIHIVYSLSKDMGLPGFRVGIVYSFNDSVVSCARKMSSFGLVSSQTQLMLASMLSDDQFVDNFLMESSRRLGIRHKVFTTGIKKADIACLTSNAGLFAWMDLRHLLRDRNSFESEIELWHIIIDRVKLNVSPGSSFRCTEPGWFRICFANMDDDTLHVALGRIQDFVSKNKNKIVEKASENDQVIQNKSAKKLKWTQTNLRLSFRRLYEDGLSSPGIMSPHSPLLRA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
279	N6-(pyridoxal phosphate)lysine	HIVYSLSKDMGLPGF HHHHHHHHHCCCCCE	57.96	-
279	Other	HIVYSLSKDMGLPGF HHHHHHHHHCCCCCE	57.96	-
483	Phosphorylation	LYEDGLSSPGIMSPH HHHCCCCCCCCCCCC	31.99	15539472
488	Phosphorylation	LSSPGIMSPHSPLLR CCCCCCCCCCCCCCC	19.96	15539472
491	Phosphorylation	PGIMSPHSPLLRA-- CCCCCCCCCCCCC--	22.19	14593172

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of 1A12_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of 1A12_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of 1A12_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of 1A12_ARATH !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of 1A12_ARATH

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphorylation of 1-aminocyclopropane-1-carboxylic acid synthase byMPK6, a stress-responsive mitogen-activated protein kinase, inducesethylene biosynthesis in Arabidopsis."; Liu Y., Zhang S.; Plant Cell 16:3386-3399(2004). Cited for: PHOSPHORYLATION AT SER-483; SER-488 AND SER-491.	15539472 [Abstract]