1433T_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 1433T_RAT
• UniProt AC: P68255
• Protein Name: 14-3-3 protein theta
• Gene Name: Ywhaq
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 245
• Subcellular Localization: Cytoplasm.
• Protein Description: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity)..
• Protein Sequence: MEKTELIQKAKLAEQAERYDDMATCMKAVTEQGAELSNEERNLLSVAYKNVVGGRRSAWRVISSIEQKTDTSDKKLQLIKDYREKVESELRSICTTVLELLDKYLIANATNPESKVFYLKMKGDYFRYLAEVACGDDRKQTIENSQGAYQEAFDISKKEMQPTHPIRLGLALNFSVFYYEILNNPELACTLAKTAFDEAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDSAGEECDAAEGAEN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEKTELIQ -------CCHHHHHH	12.29	-
3	Acetylation	-----MEKTELIQKA -----CCHHHHHHHH	46.10	22902405
9	Ubiquitination	EKTELIQKAKLAEQA CHHHHHHHHHHHHHH	40.26	-
11	Acetylation	TELIQKAKLAEQAER HHHHHHHHHHHHHHH	56.09	72611869
11	Ubiquitination	TELIQKAKLAEQAER HHHHHHHHHHHHHHH	56.09	-
45	Phosphorylation	NEERNLLSVAYKNVV HHHHHHHHHHHHCHH	14.10	27097102
48	Phosphorylation	RNLLSVAYKNVVGGR HHHHHHHHHCHHCCC	10.84	23984901
49	Ubiquitination	NLLSVAYKNVVGGRR HHHHHHHHCHHCCCH	33.26	-
49	Acetylation	NLLSVAYKNVVGGRR HHHHHHHHCHHCCCH	33.26	22902405
63	Phosphorylation	RSAWRVISSIEQKTD HHHHHHHHHHHHCCC	23.54	25403869
64	Phosphorylation	SAWRVISSIEQKTDT HHHHHHHHHHHCCCC	21.01	22673903
68	Acetylation	VISSIEQKTDTSDKK HHHHHHHCCCCCHHH	35.26	22902405
68	Ubiquitination	VISSIEQKTDTSDKK HHHHHHHCCCCCHHH	35.26	-
74	Acetylation	QKTDTSDKKLQLIKD HCCCCCHHHHHHHHH	55.97	22902405
82	Nitration	KLQLIKDYREKVESE HHHHHHHHHHHHHHH	18.70	-
85	Acetylation	LIKDYREKVESELRS HHHHHHHHHHHHHHH	42.16	22902405
92	Phosphorylation	KVESELRSICTTVLE HHHHHHHHHHHHHHH	34.34	-
104	Nitration	VLELLDKYLIANATN HHHHHHHHHHHCCCC	11.74	-
115	Acetylation	NATNPESKVFYLKMK CCCCCCCCEEEEEEC	34.40	22902405
120	Ubiquitination	ESKVFYLKMKGDYFR CCCEEEEEECCCHHH	27.47	-
120	Acetylation	ESKVFYLKMKGDYFR CCCEEEEEECCCHHH	27.47	13580569
122	Acetylation	KVFYLKMKGDYFRYL CEEEEEECCCHHHHH	47.22	24623897
139	Ubiquitination	VACGDDRKQTIENSQ HHCCCCHHHHHHHCC	59.80	-
157	Acetylation	QEAFDISKKEMQPTH HHHHHCCHHHCCCCC	53.76	22902405
157	Ubiquitination	QEAFDISKKEMQPTH HHHHHCCHHHCCCCC	53.76	-
210	Phosphorylation	LDTLNEDSYKDSTLI HHCCCCCCCCCHHHH	28.09	22673903
214	Phosphorylation	NEDSYKDSTLIMQLL CCCCCCCHHHHHHHH	22.44	22673903
215	Phosphorylation	EDSYKDSTLIMQLLR CCCCCCHHHHHHHHH	30.36	22673903
226	Phosphorylation	QLLRDNLTLWTSDSA HHHHCCCEEEECCCC	26.89	28551015
229	Phosphorylation	RDNLTLWTSDSAGEE HCCCEEEECCCCCCC	26.26	27097102
230	Phosphorylation	DNLTLWTSDSAGEEC CCCEEEECCCCCCCC	20.27	27097102
232	Phosphorylation	LTLWTSDSAGEECDA CEEEECCCCCCCCCH	37.63	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
232	S	Phosphorylation	Kinase	CK1	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of 1433T_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 1433T_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of 1433T_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.