1433G_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 1433G_RAT
• UniProt AC: P61983
• Protein Name: 14-3-3 protein gamma
• Gene Name: Ywhag
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 247
• Subcellular Localization: Cytoplasm.
• Protein Description: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner..
• Protein Sequence: MVDREQLVQKARLAEQAERYDDMAAAMKNVTELNEPLSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTSADGNEKKIEMVRAYREKIEKELEAVCQDVLSLLDNYLIKNCSETQYESKVFYLKMKGDYYRYLAEVATGEKRATVVESSEKAYSEAHEISKEHMQPTHPIRLGLALNYSVFYYEIQNAPEQACHLAKTAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDDDGGEGNN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MVDREQLV -------CCCHHHHH	6.80	-
2	Acetylation	------MVDREQLVQ ------CCCHHHHHH	10.78	-
10	Ubiquitination	DREQLVQKARLAEQA CHHHHHHHHHHHHHH	28.17	-
10	Acetylation	DREQLVQKARLAEQA CHHHHHHHHHHHHHH	28.17	22902405
20	Phosphorylation	LAEQAERYDDMAAAM HHHHHHHHHHHHHHH	14.06	13581869
28	Acetylation	DDMAAAMKNVTELNE HHHHHHHHCHHHHCC	43.47	22902405
46	Phosphorylation	NEERNLLSVAYKNVV HHHHHHHHHHHHHHH	14.10	27097102
49	Phosphorylation	RNLLSVAYKNVVGAR HHHHHHHHHHHHCCC	10.84	23984901
50	Acetylation	NLLSVAYKNVVGARR HHHHHHHHHHHCCCC	33.26	13581859
50	Ubiquitination	NLLSVAYKNVVGARR HHHHHHHHHHHCCCC	33.26	-
59	Phosphorylation	VVGARRSSWRVISSI HHCCCCCCCEEECCC	19.65	13577399
64	Phosphorylation	RSSWRVISSIEQKTS CCCCEEECCCCHHCC	23.54	63847021
65	Phosphorylation	SSWRVISSIEQKTSA CCCEEECCCCHHCCC	21.01	22673903
69	Acetylation	VISSIEQKTSADGNE EECCCCHHCCCCCCH	31.49	22902405
69	Ubiquitination	VISSIEQKTSADGNE EECCCCHHCCCCCCH	31.49	-
70	Phosphorylation	ISSIEQKTSADGNEK ECCCCHHCCCCCCHH	28.92	23984901
71	Phosphorylation	SSIEQKTSADGNEKK CCCCHHCCCCCCHHH	31.25	30240740
77	Acetylation	TSADGNEKKIEMVRA CCCCCCHHHHHHHHH	64.15	22902405
77	Ubiquitination	TSADGNEKKIEMVRA CCCCCCHHHHHHHHH	64.15	-
78	Acetylation	SADGNEKKIEMVRAY CCCCCHHHHHHHHHH	37.41	22902405
107	Phosphorylation	VLSLLDNYLIKNCSE HHHHHHHHHHHCCCC	14.96	28689409
117	Phosphorylation	KNCSETQYESKVFYL HCCCCCCCCCEEEEE	29.59	13581887
119	Phosphorylation	CSETQYESKVFYLKM CCCCCCCCEEEEEEE	29.23	28689409
120	Ubiquitination	SETQYESKVFYLKMK CCCCCCCEEEEEEEC	25.15	-
125	Ubiquitination	ESKVFYLKMKGDYYR CCEEEEEEECCHHHH	27.47	-
125	Acetylation	ESKVFYLKMKGDYYR CCEEEEEEECCHHHH	27.47	13581875
127	Acetylation	KVFYLKMKGDYYRYL EEEEEEECCHHHHHH	47.22	14505009
127	Ubiquitination	KVFYLKMKGDYYRYL EEEEEEECCHHHHHH	47.22	-
133	Phosphorylation	MKGDYYRYLAEVATG ECCHHHHHHHHHHCC	8.31	22673903
142	Acetylation	AEVATGEKRATVVES HHHHCCCCEEEEEEC	48.99	22902405
142	Ubiquitination	AEVATGEKRATVVES HHHHCCCCEEEEEEC	48.99	-
145	Phosphorylation	ATGEKRATVVESSEK HCCCCEEEEEECCHH	29.17	-
152	Ubiquitination	TVVESSEKAYSEAHE EEEECCHHHHHHHHH	55.35	-
152	Acetylation	TVVESSEKAYSEAHE EEEECCHHHHHHHHH	55.35	22902405
155	Phosphorylation	ESSEKAYSEAHEISK ECCHHHHHHHHHHCH	32.92	23984901
162	Ubiquitination	SEAHEISKEHMQPTH HHHHHHCHHHCCCCC	58.25	-
162	Acetylation	SEAHEISKEHMQPTH HHHHHHCHHHCCCCC	58.25	22902405
215	Phosphorylation	LDTLNEDSYKDSTLI HHCCCCCCCCCHHHH	28.09	22673903
219	Phosphorylation	NEDSYKDSTLIMQLL CCCCCCCHHHHHHHH	22.44	22673903
220	Phosphorylation	EDSYKDSTLIMQLLR CCCCCCHHHHHHHHH	30.36	22673903
231	Phosphorylation	QLLRDNLTLWTSDQQ HHHHCCCEEEECCCC	26.89	22673903
234	Phosphorylation	RDNLTLWTSDQQDDD HCCCEEEECCCCCCC	26.07	22673903
235	Phosphorylation	DNLTLWTSDQQDDDG CCCEEEECCCCCCCC	23.11	22673903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of 1433G_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of 1433G_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 1433G_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of 1433G_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.