UniprotKB/SwissProt ID: X2JAU8 (X2JAU8)
Gene Name:
nwk
Organism: Drosophila melanogaster (Fruit fly)
Function: Adapter protein that provides a link between vesicular membrane traffic and the actin assembly machinery. Acts together with Cdc42 to stimulate actin nucleation mediated by WASp and the ARP2/3 complex (PubMed:18701694, PubMed:27601635). Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and causes local membrane deformation (PubMed:23761074, PubMed:26686642). Required for normal structure and function of synapses at the neuromuscular junction (PubMed:14980202, PubMed:18498733, PubMed:18701694, PubMed:21464232, PubMed:26567222, PubMed:26686642, PubMed:27601635, PubMed:29568072). Plays a role in synaptic vesicle trafficking (PubMed:29568072). Required for the release of a normal number of synaptic vesicles per action potential (PubMed:26567222)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endomembrane system. Synapse. Cell projection, axon. Presynaptic cell membrane. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Recycling endosome
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