UniprotKB/SwissProt ID: W8DXL4 (W8DXL4)
Gene Name:
Lrit3
Organism: Mus musculus (Mouse)
Function: Plays a role in the synapse formation and synaptic transmission between cone photoreceptor cells and retinal bipolar cells (PubMed:25997951, PubMed:26427409, PubMed:28334377). Required for normal transmission of a light-evoked stimulus from the cone photoreceptor cells to the ON-bipolar cells and ON-ganglion cells in the inner retina (PubMed:26427409, PubMed:28334377). Required in retinal ON-bipolar cells for normal localization of the cation channel TRPM1 at dendrite tips (PubMed:25997951). Seems to play a specific role in synaptic contacts made by ON-bipolar cells with cone photoreceptor pedicles (PubMed:28334377). May also have a role in cone synapse formation (PubMed:25997951, PubMed:28334377). Might facilitate FGFR1 exit from the endoplasmic reticulum to the Golgi (By similarity). Could be a regulator of the FGFRs (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell projection, dendrite. Perikaryon. Endoplasmic reticulum membrane
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