UniprotKB/SwissProt ID: W5P3P0 (W5P3P0)
Gene Name:
FXYD1
Organism: Ovis aries (Sheep)
Function: Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane, sarcolemma. Apical cell membrane. Membrane, caveola. Cell membrane, sarcolemma, T-tubule
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