Protein Name:
Actin-depolymerizing factor 4
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UniprotKB/SwissProt ID: Q9ZSK3 (Q9ZSK3)
Gene Name:
ADF4
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (PubMed:19346440, PubMed:22010035). Contributes to the stochastic dynamic turnover of actin filaments (PubMed:22010035). Binds monomeric actin (G-actin) with a marked preference for the ADP-loaded form and inhibits the rate of nucleotide exchange on G-actin. Involved in resistance triggered by the effector AvrPphB of Pseudomonas syringae pv tomato (Pst). May modulate the AvrPphB-RPS5-mediated defense signal transduction pathway (PubMed:19346440). During AvrPphB-triggered resistance signaling pathway, involved in the control of MPK3 and MPK6 activation, via the coordinated regulation of actin cytoskeletal dynamics and RPS5 resistance gene transcription (PubMed:23144618). During innate immune response triggered by the bacterial elf26 peptide, the inhibition of ADF4 regulates actin dynamics in order to execute key events associated with pattern-triggered immunity (PTI), such as cell wall fortification and transcriptional activation of defense gene markers (PubMed:24464292)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytoskeleton
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9ZSK3
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
80 |
YDFDFVTAEN C QKSKIFFIAW |
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