UniprotKB/SwissProt ID: Q9Z2A9 (Q9Z2A9)
Gene Name:
Ggt5
Organism: Mus musculus (Mouse)
Function: Cleaves the gamma-glutamyl bond of extracellular glutathione tripeptide (gamma-Glu-Cys-Gly) and certain glutathione conjugates (PubMed:11463821, PubMed:12163373, PubMed:30842656, PubMed:9774450). Hydrolyzes glutathione releasing L-Glu and Cys-Gly dipeptide which is further metabolized to maintain extracellular cysteine levels but also to provide cysteine necessary for intracellular glutathione synthesis (By similarity). Among glutathione-S-conjugates metabolizes leukotriene C4 (LTC4) and S-geranylgeranyl-glutathione (GGG), but is inactive toward gamma-glutamyl leucine (PubMed:11463821, PubMed:12163373, PubMed:9774450). Converts extracellular LTC4 to LTD4 during acute inflammatory response (PubMed:11463821). Acts as a negative regulator of GGG bioactivity. GGT5 (via GGG catabolism) and ABCC1 (via extracellular transport) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centers in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to bone marrow parenchyma (PubMed:30842656, PubMed:34088745). The transpeptidation reaction, i.e. the transfer of gamma-glutamyl moiety to an acceptor molecule to yield a new gamma-glutamyl compound requires high concentration of dipeptide acceptor and is considered nonphysiological (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane
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