Protein Name:
Vesicle-associated membrane protein-associated protein A
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UniprotKB/SwissProt ID: Q9Z270 (Q9Z270)
Gene Name:
Vapa
Organism: Rattus norvegicus (Rat)
Function: Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44. STARD3-VAPA interaction enables cholesterol transfer from the ER to endosomes. Via interaction with WDR44 participates in neosynthesized protein export. In addition, recruited to the plasma membrane through OSBPL3 binding. The OSBPL3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology (By similarity). May play a role in vesicle trafficking (PubMed:19289470)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane. Cell membrane. Cell junction, tight junction. Nucleus membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9Z270
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
179 |
DTETRKLMEE C KRLQGEMMKL |
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