Protein Name:
Ubiquitin-conjugating enzyme E2 A
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UniprotKB/SwissProt ID: Q9Z255 (Q9Z255)
Gene Name:
Ube2a
Organism: Mus musculus (Mouse)
Function: E2 ubiquitin-conjugating enzyme that accepts ubiquitin from the ubiquitin-activating enzyme E1 and transfers it to a E3 ubiquitin-protein ligase (By similarity). In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination (By similarity). Together with the E3 enzyme BRE1 (RNF20 and/or RNF40), plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1 (By similarity). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation (By similarity). Involved in mitophagy by acting as a E2 ubiquitin-conjugating enzyme for PRKN (PubMed:23685073). In association with the E3 enzyme UBR4, is involved in N-end rule-dependent protein degradation (By similarity). In association with the E3 ubiquitin-protein ligase complex SIFI, inhibits the mitochondrial stress response by acting as a E2 ubiquitin-conjugating enzyme for UBR4 and KCMF1 (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Late endosome. Lysosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9Z255
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
88 |
HPNVYADGSI C LDILQNRWSP |
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