UniprotKB/SwissProt ID: Q9Z239 (Q9Z239)
Gene Name:
Fxyd1
Organism: Mus musculus (Mouse)
Function: Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell (PubMed:15563542, PubMed:18065526). Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated (By similarity). Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (PubMed:21454534). Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone (PubMed:19187398)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane, sarcolemma. Apical cell membrane. Membrane, caveola. Cell membrane, sarcolemma, T-tubule
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