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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Peroxiredoxin-4

UniprotKB/SwissProt ID: Q9Z0V5 (Q9Z0V5)

Gene Name: Prdx4

Organism: Rattus norvegicus (Rat)

Function: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Endoplasmic reticulum. Secreted

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR000866 AhpC/TSA
IPR050217 Peroxiredoxin
IPR019479 Peroxiredoxin_C
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain

The S-nitrosylation sites of Q9Z0V5

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 150 FKSINTEVVA C SVDSQFTHLA   
2 247 FQYTDKHGEV C PAGWKPGSET   
3 53 DDRFRTRENE C HFYAGGQVYP