UniprotKB/SwissProt ID: Q9Z0E6 (Q9Z0E6)
Gene Name:
Gbp2
Organism: Mus musculus (Mouse)
Function: Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (PubMed:18025219, PubMed:24715728, PubMed:24739961, PubMed:25774715, PubMed:25774716, PubMed:27693356, PubMed:30062052). Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (By similarity). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (PubMed:24715728, PubMed:24739961, PubMed:25774715, PubMed:25774716). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (PubMed:24715728, PubMed:24739961, PubMed:25774715, PubMed:25774716). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis, such as Gm12250/Irgb10: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (PubMed:24715728, PubMed:24739961, PubMed:25774715, PubMed:25774716, PubMed:27693356, PubMed:30062052). Confers protection to the protozoan pathogen Toxoplasma gondii (PubMed:18025219). Independently of its GTPase activity, acts as an inhibitor of various viruses infectivity by inhibiting FURIN-mediated maturation of viral envelope proteins (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasmic vesicle membrane. Golgi apparatus membrane. Cytoplasm. Cytoplasm, perinuclear region
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