UniprotKB/SwissProt ID: Q9YLR0 (Q9YLR0)
Gene Name:
Organism: Hepatitis E virus genotype 3 (isolate Human/United States/US2) (HEV-3)
Function: Small multifunctional phosphoprotein involved in virion morphogenesis, egress and counteracting host innate immunity. Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins involved in vesicle formation pathway. Also acts as a viroporin and forms ion conductive pores allowing viral particle release. Impairs the generation of type I interferon by down-regulating host TLR3 and TLR7 as well as their downstream signaling pathways. Down-regulates the phosphorylation of host IRF3 via the interaction with host SIRP-alpha, thereby inhibiting IFN-I expression. Interacts with host microtubules
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Host endoplasmic reticulum membrane. Host cytoplasm, host cytoskeleton. Virion. Host cell membrane
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