Protein Name:
Proton-coupled zinc antiporter SLC30A1
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UniprotKB/SwissProt ID: Q9Y6M5 (Q9Y6M5)
Gene Name:
SLC30A1
Organism: Homo sapiens (Human)
Function: Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (PubMed:31471319). Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells (By similarity). In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them (PubMed:32441444). Forms a complex with TMC6/EVER1 and TMC8/EVER2 at the ER membrane of keratynocytes which facilitates zinc uptake into the ER (PubMed:18158319). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Basolateral cell membrane. Cytoplasmic vesicle membrane. Cytoplasm. Endoplasmic reticulum membrane. Golgi apparatus membrane. Nucleus membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9Y6M5
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
390 |
SRIIATAHIK C EDPTSYMEVA |
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| 2 |
437 |
KSSVVPCELA C RTQCALKQCC |
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| 3 |
447 |
CRTQCALKQC C GTLPQAPSGK |
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| 4 |
469 |
AEKTPAVSIS C LELSNNLEKK |
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