Protein Name:
2'-5'-oligoadenylate synthase 3
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UniprotKB/SwissProt ID: Q9Y6K5 (Q9Y6K5)
Gene Name:
OAS3
Organism: Homo sapiens (Human)
Function: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9Y6K5
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
350 |
WKGPGLPRAG C SGLGHPIQLD |
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| 2 |
574 |
QVYSRLLTSG C QEGEHKACFA |
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| 3 |
582 |
SGCQEGEHKA C FAELRRNFMN |
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| 4 |
850 |
ISEIRAQLEA C QQERQFEVKF |
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