Protein Name:
Mitochondrial carrier homolog 2
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UniprotKB/SwissProt ID: Q9Y6C9 (Q9Y6C9)
Gene Name:
MTCH2
Organism: Homo sapiens (Human)
Function: Protein insertase that mediates insertion of transmembrane proteins into the mitochondrial outer membrane (PubMed:36264797). Catalyzes insertion of proteins with alpha-helical transmembrane regions, such as signal-anchored, tail-anchored and multi-pass membrane proteins (PubMed:36264797). Does not mediate insertion of beta-barrel transmembrane proteins (PubMed:36264797). Also acts as a receptor for the truncated form of pro-apoptotic BH3-interacting domain death agonist (p15 BID) and has therefore a critical function in apoptosis (By similarity). Regulates the quiescence/cycling of hematopoietic stem cells (HSCs) (By similarity). Acts as a regulator of mitochondrial fusion, essential for the naive-to-primed interconversion of embryonic stem cells (ESCs) (By similarity). Acts as a regulator of lipid homeostasis and has a regulatory role in adipocyte differentiation and biology (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion outer membrane
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Graphical Visualization of S-nitrosylation Sites:
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| InterPro ID |
Domain Name |
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IPR018108
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Mitochondrial_sb/sol_carrier |
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IPR023395
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Mt_carrier_dom_sf |
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The S-nitrosylation sites of Q9Y6C9
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
160 |
VQFIGRESKY C GLCDSIITIY |
CCHHHHHHHH C CCCCHHCCCC |
3.74% |
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| 2 |
49 |
IGRNIFGRQV C QLPGLFSYAQ |
CCHHHHHHHH C CCCCHHCCCC |
2.32% |
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| 3 |
79 |
GLFTGLTPRL C SGVLGTVVHG |
CCHHHHHHHH C CCCCHHCCCC |
3.34% |
24105792
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