Protein Name:
Transforming acidic coiled-coil-containing protein 3
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UniprotKB/SwissProt ID: Q9Y6A5 (Q9Y6A5)
Gene Name:
TACC3
Organism: Homo sapiens (Human)
Function: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9Y6A5
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
206 |
TPASETLEDP C RTESQHKAET |
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| 2 |
426 |
IPFGGDTKSG C SEAQPPESPE |
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| 3 |
502 |
NSASTSLPTS C PGSEPVPTHQ |
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