Protein Name:
Chloride intracellular channel protein 4
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UniprotKB/SwissProt ID: Q9Y696 (Q9Y696)
Gene Name:
CLIC4
Organism: Homo sapiens (Human)
Function: In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (PubMed:25581026, PubMed:37759794). Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions (By similarity) (PubMed:16176272). Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Promotes cell-surface expression of HRH3
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle membrane. Nucleus. Cell membrane. Mitochondrion. Cell junction. Endoplasmic reticulum membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9Y696
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
100 |
KIEEFLEEVL C PPKYLKLSPK |
CCCCCCCCCC C HHHCCCHHHH |
7.01% |
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| 2 |
234 |
AYSRDEFTNT C PSDKEVEIAY |
CCCCCCCCCC C HHHCCCHHHH |
3.09% |
22178444
16648260
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| 3 |
35 |
AGSDGESIGN C PFSQRLFMIL |
CCCCCCCCCC C HHHCCCHHHH |
2.8% |
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