Protein Name:
Lipid droplet-regulating VLDL assembly factor AUP1
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UniprotKB/SwissProt ID: Q9Y679 (Q9Y679)
Gene Name:
AUP1
Organism: Homo sapiens (Human)
Function: Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome (PubMed:18711132, PubMed:21857022). Plays a role in lipid droplet formation (PubMed:21857022). Induces lipid droplet clustering (PubMed:24039768). Recruits ubiquitin-conjugating enzyme UBE2G2 to lipid droplets which facilitates its interaction with ubiquitin ligases AMFR/gp78 and RNF139/TRC8, leading to sterol-induced ubiquitination of HMGCR and its subsequent proteasomal degradation (PubMed:21127063, PubMed:23223569). Also required for the degradation of INSIG1, SREBF1 and SREBF2 (PubMed:23223569). Plays a role in regulating assembly and secretion of very low density lipoprotein particles and stability of apolipoprotein APOB (PubMed:28183703) (Microbial infection) Following Dengue virus infection, required for induction of lipophagy which facilitates production of virus progeny particles
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane. Lipid droplet. Cytoplasmic vesicle, autophagosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9Y679
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
325 |
VIQRDLAKTG C VDLTITNLLE |
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| 2 |
70 |
VLRRFVVRTM C AVLGLVARQE |
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