Protein Name:
Junctional adhesion molecule A
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UniprotKB/SwissProt ID: Q9Y624 (Q9Y624)
Gene Name:
F11R
Organism: Homo sapiens (Human)
Function: Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913). The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (PubMed:11812992). Involved in platelet activation (PubMed:10753840) (Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1 (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell junction, tight junction. Cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9Y624
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
153 |
ATIGNRAVLT C SEQDGSPPSE |
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| 2 |
50 |
IPENNPVKLS C AYSGFSSPRV |
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| 3 |
74 |
FDQGDTTRLV C YNNKITASYE |
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