UniprotKB/SwissProt ID: Q9Y5Q5 (Q9Y5Q5)
Gene Name:
CORIN
Organism: Homo sapiens (Human)
Function: Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) and brain natriuretic peptide (NPPB) processing (PubMed:10880574, PubMed:20489134, PubMed:21288900, PubMed:21763278). Converts through proteolytic cleavage the non-functional propeptides NPPA and NPPB into their active hormones, ANP and BNP(1-32) respectively, thereby regulating blood pressure in the heart and promoting natriuresis, diuresis and vasodilation (PubMed:10880574, PubMed:20489134, PubMed:21288900, PubMed:21763278). Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus (PubMed:22437503). Also acts as a regulator of sodium reabsorption in kidney (By similarity) Has weaker endopeptidase activity compared to isoform 1
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cell membrane. Secreted. Secreted. Secreted
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