Protein Name:
RNA polymerase II subunit A C-terminal domain phosphatase
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UniprotKB/SwissProt ID: Q9Y5B0 (Q9Y5B0)
Gene Name:
CTDP1
Organism: Homo sapiens (Human)
Function: Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Midbody
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9Y5B0
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
277 |
FSHRILSRDE C IDPFSKTGNL |
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| 2 |
429 |
LAGAPEPQGS C AQGGRVAPGQ |
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