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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Protein phosphatase methylesterase 1

UniprotKB/SwissProt ID: Q9Y570 (Q9Y570)

Gene Name: PPME1

Organism: Homo sapiens (Human)

Function: Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR000073 AB_hydrolase_1
IPR029058 AB_hydrolase_fold
IPR016812 PPase_methylesterase_euk

The S-nitrosylation sites of Q9Y570

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 238 RVSMVGQVKQ C EGITSPEGSK  CCHHHHHHHH C CCCCCCCCCC  4.24%
2 312 FRGLSNLFLS C PIPKLLLLAG  CCHHHHHHHH C CCCCCCCCCC  3.73% 19483679
3 347 GKFQMQVLPQ C GHAVHEDAPD  CCHHHHHHHH C CCCCCCCCCC  3.99%
4 381 RFAEPIGGFQ C VFPGC-----  CCHHHHHHHH C CCCCCCCCCC  2.96%